长链非编码RNA linc-UBC1是胃癌的负性预后因素，并具有肿瘤促癌活性。
Long noncoding RNA linc-UBC1 is negative prognostic factor and exhibits tumor pro-oncogenic activity in gastric cancer.
作者信息
Hu Yiren, Pan Jianghua, Wang Yi, Li Linjing, Huang Yi
机构信息
Department of General Surgery, Wenzhou People's Hospital, The Third Clinical College of Wenzhou Medical University Wenzhou, China.
出版信息
Int J Clin Exp Pathol. 2015 Jan 1;8(1):594-600. eCollection 2015.
Abstract
Despite the advances in the management of gastric cancer, the prognosis of advanced gastric cancer remains relatively poor. Thus, it is of urgent need to identify novel prognostic markers and therapeutic targets of gastric cancer. A growing volume of literature has indicated that lncRNAs are differentially expressed in a diverse array of cancer and play an important role in the development of cancer. Linc-UBC1, a recently identified long noncoding RNA, was initially found to be upregulated in bladder cancer. However, the role of linc-UBC1 in gastric cancer remains to be elusive. In this study, we found that linc-UBC1 was significantly upregulated in gastric cancer tissues compared to adjacent normal tissues. Furthermore, high linc-UBC1 expression was associated with lymph-node metastasis, tumor size, TNM stage and poorer prognosis. Inhibition of linc-UBC1 suppressed the proliferation, motility and invasion of gastric cancer cells. Our study suggests that linc-UBC1 may represent a novel diagnostic, prognostic biomarker and a potential therapeutic target of gastric cancer.
摘要
尽管胃癌的治疗取得了进展，但晚期胃癌的预后仍然相对较差。因此，迫切需要确定胃癌新的预后标志物和治疗靶点。越来越多的文献表明，长链非编码RNA（lncRNAs）在多种癌症中差异表达，并在癌症发展中发挥重要作用。Linc-UBC1是最近发现的一种长链非编码RNA，最初发现它在膀胱癌中上调。然而，Linc-UBC1在胃癌中的作用仍不清楚。在本研究中，我们发现与相邻正常组织相比，Linc-UBC1在胃癌组织中显著上调。此外，Linc-UBC1高表达与淋巴结转移、肿瘤大小、TNM分期及较差的预后相关。抑制Linc-UBC1可抑制胃癌细胞的增殖、运动和侵袭。我们的研究表明，Linc-UBC1可能是一种新的胃癌诊断、预后生物标志物和潜在的治疗靶点。
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