Medical School of Ningbo University, Ningbo 315000, Zhejiang Province, China.
Gastroenterology Department, Ningbo First Hospital, Ningbo 315000, Zhejiang Province, China.
World J Gastroenterol. 2018 Sep 7;24(33):3724-3737. doi: 10.3748/wjg.v24.i33.3724.
Gastric cancer (GC) is one of the most frequently diagnosed malignant diseases. The molecular mechanisms of metastasis remain unclear. Recently, studies have shown that long non-coding RNAs (lncRNAs) play critical roles in metastasis. Therefore, deeper understanding of this mechanism could provide potential diagnostic tools and therapeutic targets for metastatic GC. This review focuses on dysregulated lncRNAs in GC metastases. Due to the identification of multiple diverse mechanisms involved in GC metastasis, we classified them into seven categories, including lncRNAs related to epithelial-mesenchymal transition, regulation of degradation of extracellular matrix, angiopoiesis, vasculogenic mimicry, and immunologic escape. As the TNM stage is pivotal for evaluating the severity and prognosis of GC patients, we summarize the lncRNAs relevant to lymphatic metastasis, distant metastasis and TNM classification. This review summarizes the lncRNAs related to metastasis, which may provide insight into the mechanisms, and provide potential markers for prognostic prediction and monitoring the relapse of GC.
胃癌（GC）是最常见的恶性疾病之一。转移的分子机制仍不清楚。最近的研究表明，长非编码 RNA（lncRNA）在转移中发挥着关键作用。因此，深入了解这一机制可以为转移性 GC 提供潜在的诊断工具和治疗靶点。本综述重点介绍了 GC 转移中失调的 lncRNA。由于鉴定出多种不同的 GC 转移机制，我们将它们分为七类，包括与上皮-间充质转化、细胞外基质降解调控、血管生成、血管生成拟态和免疫逃逸相关的 lncRNA。由于 TNM 分期对于评估 GC 患者的严重程度和预后至关重要，我们总结了与淋巴转移、远处转移和 TNM 分类相关的 lncRNA。本综述总结了与转移相关的 lncRNA，这可能为机制提供了深入的了解，并为 GC 的预后预测和复发监测提供了潜在的标志物。
