Guo Tao, Yin Rui-Xing, Chen Xia, Bin Yuan, Nie Rong-Jun, Li Hui
Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University Nanning 530021, Guangxi, China.
Clinical Laboratory of The Affiliated Cancer Hospital, Guangxi Medical University Nanning 530021, Guangxi, China.
Int J Clin Exp Pathol. 2015 Jan 1;8(1):665-81. eCollection 2015.
The objective of the present study was to detect the association of the rs7934205 single nucleotide polymorphism (SNP) near the Suppressor of Ty, domain containing 1 gene (SPTY2D1) and serum lipid levels between males and females in the Mulao and Han populations. Genotyping of SPTY2D1 rs7934205 SNP was performed in 933 of Mulao and 865 of Han participants using polymerase chain reaction and restriction fragment length polymorphism. The T allele frequency was different between Mulao males and females (23.2% vs. 27.9%, P = 0.018). The genotype and allele frequencies were also different between Han males and females (P = 0.020 and P = 0.004; respectively). Serum levels of apolipoprotein (Apo) A1 in Mulao males; and total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), ApoA1 and ApoB in Mulao females were different between the CC and CT/TT genotypes (P < 0.05). Serum TC, ApoB levels in Han males, and ApoB levels in Han females were different between the CC and CT/TT genotypes (P < 0.05). The subjects with CT/TT genotype in both Mulao and Han males and females have more favorable lipid profiles than those with CC genotype. These findings suggest that the association between the SPTY2D1 rs7934205 SNP and serum lipid levels might have ethnic- and/or sex-specificity.
本研究的目的是检测木佬族和汉族人群中，酪氨酸抑制因子结构域包含蛋白1基因（SPTY2D1）附近的rs7934205单核苷酸多态性（SNP）与男性和女性血清脂质水平之间的关联。采用聚合酶链反应和限制性片段长度多态性方法，对933名木佬族和865名汉族参与者进行SPTY2D1 rs7934205 SNP基因分型。木佬族男性和女性的T等位基因频率不同（23.2%对27.9%，P = 0.018）。汉族男性和女性的基因型和等位基因频率也不同（分别为P = 0.020和P = 0.004）。木佬族男性的载脂蛋白（Apo）A1血清水平；以及木佬族女性的总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、ApoA1和ApoB在CC和CT/TT基因型之间存在差异（P < 0.05）。汉族男性的血清TC、ApoB水平，以及汉族女性的ApoB水平在CC和CT/TT基因型之间存在差异（P < 0.05）。木佬族和汉族的男性和女性中，CT/TT基因型的受试者比CC基因型的受试者具有更有利的血脂谱。这些发现表明，SPTY2D1 rs7934205 SNP与血清脂质水平之间的关联可能具有种族和/或性别特异性。
