Aung Lynn-Htet-Htet, Yin Rui-Xing, Wu Jin-Zhen, Wu Dong-Feng, Wang Wei, Li Hui
Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China.
Clinical Laboratory of the Affiliated Cancer Hospital, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China.
Sci Rep. 2014 Jul 3;4:5565. doi: 10.1038/srep05565.
This study aimed to detect the association between the MLX interacting protein-like (MLXIPL), BUD13 homolog (BUD13) and zinc finger protein 259 (ZNF259) single nucleotide polymorphisms (SNPs) and serum lipid levels in the Chinese Mulao and Han populations. Genotyping of 9 SNPs was performed in 825 Mulao and 781 Han participants. The genotype and allele frequencies of ZNF259 rs2075290 and rs964184, and BUD13 rs10790162 SNPs were different between the Mulao and Han populations (P < 0.001). The SNPs of ZNF259 rs2075290 and BUD13 rs10790162 were associated with serum total cholesterol levels; ZNF259 rs2075290 and rs964184, BUD13 rs10790162, and MLXIPL rs3812316 and rs13235543 were associated with triglyceride (TG); and MLXIPL rs35332062 was associated with apolipoprotein (Apo) A1 in the Mulaos (P < 0.006-0.001). However, in the Hans, the SNPs of ZNF259 rs2075290 and BUD13 rs10790162 were associated with serum TG levels; ZNF259 rs2075290 was associated with low-density lipoprotein cholesterol and the ApoA1/ApoB ratio (P < 0.006-0.001). Significant linkage disequilibria were noted among ZNF259 rs2075290 and rs964184 and BUD13 rs10790162, and between MLXIPL rs3812316 and rs13235543 (r(2) > 0.05, P < 0.001). The haplotypes of A-C-G-A-C (rs2075290A-rs964184C-rs10790162G-rs17119975A-rs11556024C) and C-C-C-C (rs799161C-rs35332062C-rs3812316C-rs13235543C) accounted for over half of the % haplotype of each ethnic group.
本研究旨在检测中国仫佬族和汉族人群中MLX相互作用蛋白样（MLXIPL）、BUD13同源物（BUD13）和锌指蛋白259（ZNF259）单核苷酸多态性（SNP）与血脂水平之间的关联。对825名仫佬族和781名汉族参与者进行了9个SNP的基因分型。ZNF259 rs2075290和rs964184以及BUD13 rs10790162 SNP的基因型和等位基因频率在仫佬族和汉族人群之间存在差异（P < 0.001）。ZNF259 rs2075290和BUD13 rs10790162的SNP与血清总胆固醇水平相关；ZNF259 rs2075290和rs964184、BUD13 rs10790162以及MLXIPL rs3812316和rs13235543与甘油三酯（TG）相关；MLXIPL rs35332062与仫佬族人群中的载脂蛋白（Apo）A1相关（P < 0.006 - 0.001）。然而，在汉族人群中，ZNF259 rs2075290和BUD13 rs10790162的SNP与血清TG水平相关；ZNF259 rs2075290与低密度脂蛋白胆固醇和ApoA1/ApoB比值相关（P < 0.006 - 0.001）。在ZNF259 rs2075290和rs964184与BUD13 rs第10790162位之间以及MLXIPL rs3812316和rs13235543之间发现了显著的连锁不平衡（r(2) > 0.05，P < 0.001）。单倍型A - C - G - A - C（rs2075290A - rs964184C - rs10790162G - rs17119975A - rs11556024C）和C - C - C - C（rs799161C - rs35332062C - rs3812316C - rs13235543C）在每个民族的单倍型百分比中占比超过一半。
