足月儿小于胎龄儿出生后11β-羟类固醇脱氢酶2信使核糖核酸与胰岛素敏感性的关系
Relationship between 11β-HSD2 mRNA and insulin sensitivity in term small-for-gestational age neonates after birth.
作者信息
Zhu Ziyang, Liu Qianqi
机构信息
Department of Endocrinology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Vice-Chief Physician 72 Guangzhou Road, Nanjing 210008, Jiangsu Province.
出版信息
Int J Clin Exp Pathol. 2015 Jan 1;8(1):928-32. eCollection 2015.
The aim of this study was to investigate the relationship between serum 11β-HSD2 mRNA level and insulin sensitivity in term small-for-gestational age (SGA) neonates after birth. The 38 infants were divided into two groups, the SGA group and the appropriate-for-gestational age (AGA) group. The placental 11β-HSD2 mRNA abundance and concentration of cortisol, fasting glucose, fasting insulin, adiponectin, visfatin and insulin-like growth factor-I (IGF-1) in the umbilical vein plasma were measured. The results showed that in the SGA group, neonates had lower levels of placental 11β-HSD2 mRNA and serum cortisol, and higher fasting insulin and HOMA-IR compared to AGA group. For some insulin sensitivity relative factor, levels of serum adiponectin and IGF-1 were lower while visfatin was higher in the SGA group than AGA group. Correlation analyses revealed that 11β-HSD2 mRNA level had a negative correlation with fasting insulin, HOMA-IR and visfatin.
本研究旨在探讨足月小于胎龄（SGA）新生儿出生后血清11β-羟基类固醇脱氢酶2（11β-HSD2）mRNA水平与胰岛素敏感性之间的关系。38例婴儿被分为两组，即SGA组和适于胎龄（AGA）组。测定脐静脉血浆中胎盘11β-HSD2 mRNA丰度以及皮质醇、空腹血糖、空腹胰岛素、脂联素、内脂素和胰岛素样生长因子-I（IGF-1）的浓度。结果显示，与AGA组相比，SGA组新生儿胎盘11β-HSD2 mRNA水平和血清皮质醇水平较低，空腹胰岛素和稳态模型评估胰岛素抵抗（HOMA-IR）较高。对于一些胰岛素敏感性相关因子，SGA组血清脂联素和IGF-1水平低于AGA组，而内脂素水平高于AGA组。相关性分析显示，11β-HSD2 mRNA水平与空腹胰岛素、HOMA-IR和内脂素呈负相关。
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