Kaur Sharanjit, Sharma Anand, Singh Harinder Jot
Department of Pharmacology, M.M. Medical College and Hospital Kumarhatti Solan, H.P.
Department of Physiology, M.M. Medical College and Hospital Kumarhatti Solan, H.P.
Int J Physiol Pathophysiol Pharmacol. 2014 Dec 15;6(4):216-20. eCollection 2014.
To compare the waist related anthropometric measures like waist circumference, waist-to-height ratio (WHtR), waist - hip ratio (WHR) and body mass index (BMI) as predictors of coronary artery disease (CAD) in women.
The study included 88 women aged 40-80 years. Waist circumference, hip circumference, height, weight, age, and other covariates were collected by questionnaire. The primary endpoint was incident coronary heart disease that was reported by physician. The data was analyzed statistically using χ(2)-test for quantitative data and student t-test. The significance of the results as determined in 95.0% confidence interval.
The mean age was 59.07 ± 11.53 in the study group and 54.36 ± 10.84 in the control group. The waist circumference in the study group was higher (95.443 ± 11.187) than the control group (74.886 ± 6.672) (p < 0.001). The mean waist to hip ratio (WHR) was 0.96 ± 0.08 in the study group and 0.78 ± 0.06 in the control group (p < 0.001). The mean waist to height ratio (WHtR) was 0.62 ± 0.07 in the study group and 0.48 ± 0.04 in the control group (p < 0.001). Waist derived measures were superior to BMI in predicting CAD. The unadjusted AUC (95% Confidence Interval) was 0.008 (0.006-0.095) for WHtR, 0.001 (0.00 0.002) for waist - hip ratio, and 1 (0.323-1.766) for body mass index.
Waist related anthropometric measures are important predictors as CAD risk factors among middle-aged and older women, as compared to BMI.
比较腰围、腰高比(WHtR)、腰臀比(WHR)和体重指数(BMI)等与腰围相关的人体测量指标作为女性冠状动脉疾病(CAD)预测指标的情况。
该研究纳入了88名年龄在40 - 80岁的女性。通过问卷调查收集腰围、臀围、身高、体重、年龄及其他协变量。主要终点是医生报告的冠心病发病情况。对定量数据采用χ(2)检验,对数据进行统计学分析,并采用学生t检验。结果的显著性在95.0%置信区间内确定。
研究组的平均年龄为59.07±11.53岁,对照组为54.36±10.84岁。研究组的腰围(95.443±11.187)高于对照组(74.886±6.672)(p<0.001)。研究组的平均腰臀比(WHR)为0.96±0.08,对照组为0.78±0.06(p<0.001)。研究组的平均腰高比(WHtR)为0.62±0.07,对照组为0.48±0.04(p<0.001)。在预测CAD方面,基于腰围的测量指标优于BMI。未调整的曲线下面积(95%置信区间),腰高比为0.008(0.006 - 0.095),腰臀比为0.001(0.00 - 0.002),体重指数为1(0.323 - 1.766)。
与BMI相比,与腰围相关的人体测量指标是中老年女性CAD风险因素的重要预测指标。