HIV/AIDS 患者肥胖标志物：腰围、腰臀比、腰高比和体质指数之间的一致性。

Markers of adiposity in HIV/AIDS patients: Agreement between waist circumference, waist-to-hip ratio, waist-to-height ratio and body mass index.

机构信息

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Orthopaedics Department, Southend University Hospital, Essex, United Kingdom.

出版信息

PLoS One. 2018 Mar 22;13(3):e0194653. doi: 10.1371/journal.pone.0194653. eCollection 2018.

DOI:10.1371/journal.pone.0194653

PMID:29566089

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5864036/

Abstract

BACKGROUND

Waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) are all independent predictors of cardio-metabolic risk and therefore important in HIV/AIDS patients on antiretroviral therapy at risk of increased visceral adiposity. This study aimed to assess the extent of agreement between these parameters and the body mass index (BMI), as anthropometric parameters and in classifying cardio-metabolic risk in HIV/AIDS patients.

METHODS

A secondary analysis of data from a cross-sectional study involving 200 HIV/AIDS patients was done. Anthropometric parameters were measured from participants using standard guidelines and central obesity defined according to recommended criteria. Increased cardio-metabolic risk was defined according to the standard cut-off values for all four parameters. Data were analyzed using STATA version 14.1.

RESULTS

The prevalence of WC-defined central obesity, WHR-defined central obesity and WHtR > 0.50 were 33.5%, 44.5% and 36.5%, respectively. The prevalence of BMI-defined overweight and obesity was 40.5%. After adjusting for gender and HAART status, there was a significant linear association and correlation between WC and BMI (regression equation: WC (cm) = 37.184 + 1.756 BMI (Kg/m2) + 0.825 Male + 1.002 HAART, (p < 0.001, r = 0.65)), and between WHtR and BMI (regression equation: WHtR = 0.223 + 0.011 BMI (Kg/m2)- 0.0153 Male + 0.003 HAART, (p < 0.001, r = 0.65)), but not between WHR and BMI (p = 0.097, r = 0.13). There was no agreement between the WC, WHtR and BMI, and minimal agreement between the WHR and BMI, in identifying patients with an increased cardio-metabolic risk.

CONCLUSION

Despite the observed linear association and correlation between these anthropometric parameters, the routine use of WC, WHR and WHtR as better predictors of cardio-metabolic risk should be encouraged in these patients, due to their minimal agreement with BMI in identifying HIV/AIDS patients with increased cardio-metabolic risk. HAART status does not appear to significantly affect the association between these anthropometric parameters.

摘要

背景

腰围（WC）、腰臀比（WHR）和腰高比（WHtR）均是心血管代谢风险的独立预测因子，因此对于接受抗逆转录病毒治疗且存在内脏性肥胖风险的 HIV/AIDS 患者而言十分重要。本研究旨在评估这些参数与体重指数（BMI）之间的一致性程度，以及这些参数作为人体测量参数在 HIV/AIDS 患者心血管代谢风险分类中的作用。

方法

对一项横断面研究中 200 名 HIV/AIDS 患者的数据进行了二次分析。使用标准指南测量参与者的人体测量参数，并根据推荐标准定义中心性肥胖。根据所有四个参数的标准截断值定义心血管代谢风险增加。使用 STATA 版本 14.1 分析数据。

结果

WC 定义的中心性肥胖、WHR 定义的中心性肥胖和 WHtR＞0.50 的患病率分别为 33.5%、44.5%和 36.5%。BMI 定义的超重和肥胖的患病率为 40.5%。在调整性别和抗逆转录病毒治疗（HAART）状态后，WC 与 BMI 之间存在显著的线性关联和相关性（回归方程：WC（cm）=37.184+1.756 BMI（kg/m2）+0.825 男性+1.002 HAART，（p＜0.001，r=0.65）），WHtR 与 BMI 之间也存在显著的线性关联和相关性（回归方程：WHtR=0.223+0.011 BMI（kg/m2）-0.0153 男性+0.003 HAART，（p＜0.001，r=0.65）），但 WHR 与 BMI 之间不存在显著的线性关联和相关性（p=0.097，r=0.13）。WC、WHtR 和 BMI 之间没有一致的结果，WHR 和 BMI 之间的一致性也很小，无法准确识别具有心血管代谢风险增加的患者。