迈向弥合酸碱转运体与神经元兴奋性调节之间的差距。
Towards bridging the gap between acid-base transporters and neuronal excitability modulation.
作者信息
Liu Ying, Chen Li-Ming
机构信息
Department of Biophysics and Molecular Physiology, Key Laboratory of Molecular Biophysics of Ministry of Education, Huazhong University of Science & Technology School of Life Science & Technology 1037 Luoyu Rd, Wuhan, Hubei Province, 430074, P.R. China.
出版信息
Int J Physiol Pathophysiol Pharmacol. 2014 Dec 15;6(4):221-5. eCollection 2014.
Abstract
pH homeostasis is a fundamental regulator of the function of the central nervous system. Dysfunction of acid-base transporters often results in disturbance of neuronal excitability. In a latest issue of Journal of Neuroscience, Jones et al. report that increasing intracellular bicarbonate concentration substantially stimulates the excitability of pyramidal neurons from mouse hippocampus by inhibiting KCNQ potassium channel. The finding shed important new light in understanding the molecular mechanism underlying the regulation of neuronal excitability by acid-base transporters.
摘要
pH稳态是中枢神经系统功能的基本调节因子。酸碱转运体功能障碍常导致神经元兴奋性紊乱。在最新一期的《神经科学杂志》上，琼斯等人报告称，通过抑制KCNQ钾通道，增加细胞内碳酸氢盐浓度可显著刺激小鼠海马体锥体神经元的兴奋性。这一发现为理解酸碱转运体调节神经元兴奋性的分子机制提供了重要的新线索。
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