新型隐球菌抗原阴性的新型隐球菌脑膜炎：一种新型免疫层析检测方法的评估
Cryptococcus neoformans meningitis with negative cryptococcal antigen: Evaluation of a new immunochromatographic detection assay.
作者信息
Opota O, Desgraz B, Kenfak A, Jaton K, Cavassini M, Greub G, Prod'hom G, Giulieri S
机构信息
Institute of Microbiology, Switzerland.
Infectious Diseases Service, University of Lausanne and University Hospital Center, Lausanne, Switzerland.
出版信息
New Microbes New Infect. 2014 Dec 19;4:1-4. doi: 10.1016/j.nmni.2014.12.003. eCollection 2015 Mar.
Detection of cryptococcal antigen in serum or cerebrospinal fluid allows cryptococcal meningitis diagnosis within few hours with >90% sensitivity. In an HIV-positive patient with Cryptococcus neoformans meningitis, initial antigen detection by immunoagglutination was negative. We thus evaluated a new immunochromatographic detection assay that exhibited a higher sensitivity.
检测血清或脑脊液中的隐球菌抗原可在数小时内诊断隐球菌性脑膜炎，灵敏度>90%。在一名患有新型隐球菌性脑膜炎的HIV阳性患者中，通过免疫凝集法进行的初始抗原检测为阴性。因此，我们评估了一种灵敏度更高的新型免疫层析检测方法。
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