Jagodzinska Julia, Polaniak Renata, Birkner Ewa, Kasperska-Zajac Alicja
Anaesthesiology and Intensive Therapy, Upper Silesian Medical Centre, 40-635 Katowice, Poland.
Department of Nutrition-Associated Disease Prevention, Faculty of Public Health, Ulica Piekarska 18, Medical University of Silesia in Katowice, 41-902 Bytom, Poland.
Biomed Res Int. 2015;2015:578383. doi: 10.1155/2015/578383. Epub 2015 Feb 10.
Vascular endothelial growth factor (VEGF) is a powerful enhancer of vascular permeability and inflammatory response; however its significance in chronic urticaria is poorly recognised.
To compare free circulating levels of VEGF and its soluble receptors (sVEGFR1 and VEGFR2) in patients with different forms of chronic urticaria.
The concentrations of VEGF and its receptors in plateletpoor plasma (PPP)/plasma were measured using enzyme-linked immunosorbent assay in chronic urticaria: (1) chronic spontaneous urticaria (CSU) with positive autologous serum skin test (ASST), (2) CSU with negative response to ASST, (3) CSU with concomitant euthyroid Hashimoto's thyroiditis (CSU/Hashimoto), (4) delayed pressure urticaria (DPU), and the healthy subjects.
There were no significant differences in VEGF concentration in PPP between CSU groups and the healthy subjects. Contrary, VEGF concentration was significantly higher in DPU and CSU/Hashimoto patients as compared with the healthy subjects and CSU groups. Furthermore, VEGF value in CSU/Hashimoto patients during the remission was similar to that of the active period and significantly higher than the healthy subjects; VEGF concentration was significantly correlated with TSH. Plasma concentrations of sVEGF1 and sVEGF2 were similar in chronic urticaria patients and the healthy subjects.
Increased free circulating VEGF concentration may result from the urticarial process itself as well as concomitant Hashimoto's thyroiditis.
血管内皮生长因子（VEGF）是血管通透性和炎症反应的强效增强剂；然而其在慢性荨麻疹中的意义尚未得到充分认识。
比较不同类型慢性荨麻疹患者中VEGF及其可溶性受体（sVEGFR1和VEGFR2）的游离循环水平。
采用酶联免疫吸附测定法检测慢性荨麻疹患者（1）自体血清皮肤试验（ASST）阳性的慢性自发性荨麻疹（CSU）、（2）对ASST反应阴性的CSU、（3）合并甲状腺功能正常的桥本甲状腺炎的CSU（CSU/桥本）、（4）迟发性压力性荨麻疹（DPU）以及健康受试者血小板缺乏血浆（PPP）/血浆中VEGF及其受体的浓度。
CSU各亚组与健康受试者之间PPP中VEGF浓度无显著差异。相反，与健康受试者和CSU各亚组相比，DPU和CSU/桥本患者的VEGF浓度显著更高。此外，CSU/桥本患者缓解期的VEGF值与活动期相似，且显著高于健康受试者；VEGF浓度与促甲状腺激素显著相关。慢性荨麻疹患者和健康受试者血浆中sVEGF1和sVEGF2的浓度相似。
游离循环VEGF浓度升高可能是由荨麻疹过程本身以及合并的桥本甲状腺炎导致的。
