Vandenhende-Szymanski C, Hochet B, Chevalier D, Mortuaire G
Rhinology. 2015 Mar;53(1):29-34. doi: 10.4193/Rhino14.160.
To assess subjective improvement of olfactory function following endoscopic sinus surgery (ESS) in chronic rhinosinusitis associated with nasal polyps (CRSwNP) and to analyse factors of recovery with the European Test of Olfactory Capabilities (ETOC).
We carried out a prospective study of 30 patients with CRSwNP from November 2011 to April 2013. The ETOC was filled the day before surgery and in the short term follow-up. Sixteen suprathreshold odorants with a detection task and a forced choice verbal identification task were tested.
The mean composite score (MCS) improved at 3 and 6 months. The preoperative MCS was correlated to the Lund-Mackay score and to the olfactory cleft opacification on preoperative computed tomography (CT) scan. Multivariate linear regression modelling of patients with preoperative anosmia showed that the olfactory recovery at 3 months was predicted by the preoperative Lund-Mackay score and the age, and at 6 months by the preoperative Lund-Mackay score.
With a convenient psychophysical test, we showed that olfactory cleft opacification and CT scan score could be predictive factors of olfaction disorder severity and improvement after ESS in CRSwNP. These results need to be strengthened in the long term with a larger panel of patients.
评估鼻内镜鼻窦手术（ESS）后慢性鼻窦炎伴鼻息肉（CRSwNP）患者嗅觉功能的主观改善情况，并使用欧洲嗅觉能力测试（ETOC）分析恢复因素。
我们对2011年11月至2013年4月期间的30例CRSwNP患者进行了一项前瞻性研究。在手术前一天和短期随访时填写ETOC。测试了16种阈上气味剂，包括检测任务和强制选择言语识别任务。
3个月和6个月时平均综合评分（MCS）有所改善。术前MCS与Lund-Mackay评分以及术前计算机断层扫描（CT）扫描上的嗅裂混浊相关。对术前嗅觉丧失患者的多变量线性回归模型显示，3个月时的嗅觉恢复可由术前Lund-Mackay评分和年龄预测，6个月时则由术前Lund-Mackay评分预测。
通过一项便捷的心理物理学测试，我们表明嗅裂混浊和CT扫描评分可能是CRSwNP患者ESS后嗅觉障碍严重程度和改善情况的预测因素。这些结果需要通过更大规模的患者群体进行长期强化验证。
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