新西兰黑小鼠亚系之间的显著遗传差异。
Gross genetic differences among substrains of NZB mice.
作者信息
Weiss S, Uematsu Y, D'Hoostelaere L, Alanen A
机构信息
Basel Institute for Immunology, Basel, Switzerland.
出版信息
J Immunogenet. 1989 Jun;16(3):217-21. doi: 10.1111/j.1744-313x.1989.tb00464.x.
Substrains of NZB mice have been compared by Southern blot analysis using several probes. The restriction fragment length polymorphism of probes derived from the Igh-V, Igk-V, Tcr alpha-C loci and of the long terminal repeat of the mouse mammary tumour virus revealed that NZB/BlLwPtIbm were grossly different from NZB/BlNJ and NZB/BlOla. Comparison with mouse strains of the Igk-V haplotypes a and d suggested that NZB/BlLwPtIbm contain genetic material of the C58 mouse strain.
使用几种探针通过Southern印迹分析比较了NZB小鼠的亚系。来自Igh-V、Igk-V、Tcrα-C基因座的探针以及小鼠乳腺肿瘤病毒长末端重复序列的限制性片段长度多态性表明，NZB/BlLwPtIbm与NZB/BlNJ和NZB/BlOla有很大差异。与Igk-V单倍型a和d的小鼠品系比较表明，NZB/BlLwPtIbm含有C58小鼠品系的遗传物质。
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