Raveche E S, Novotny E A, Hansen C T, Tjio J H, Steinberg A D
J Exp Med. 1981 May 1;153(5):1187-97. doi: 10.1084/jem.153.5.1187.
The genetic basis for autoimmunity in NZB mice has been investigated through analysis of recombinant inbred lines produced by mating NZB mice with two different non-autoimmune strains. Several genes (at least six) were found to be necessary for the production of eight traits characteristic of the NZB mice that were studied. No fundamental genetic defect (an "autoimmunity gene") was identified that could give rise to the various autoimmune traits studied. This study strongly suggests that NZB disease results from the actions of several separate genes that together result in the characteristic manifestations of autoimmunity.
通过将NZB小鼠与两种不同的非自身免疫品系交配产生重组近交系进行分析,研究了NZB小鼠自身免疫的遗传基础。发现有几个基因(至少六个)是产生所研究的NZB小鼠八个特征性状所必需的。未发现能引发所研究的各种自身免疫性状的根本遗传缺陷(“自身免疫基因”)。这项研究有力地表明,NZB疾病是由几个单独的基因共同作用导致自身免疫特征性表现的结果。