Pratesi Andrea, Moores Andrew P, Downes Ciara, Grierson James, Maddox Thomas W
Anderson Moores Veterinary Specialists, Winchester, United Kingdom.
Torrington Orthopaedics, Brighouse, United Kingdom.
Vet Surg. 2015 Jul;44(5):653-60. doi: 10.1111/vsu.12326. Epub 2015 Mar 10.
To investigate whether administration of postoperative oral antimicrobial drugs has a beneficial effect on preventing surgical site infections (SSI) in clean orthopedic surgery involving stainless steel plating systems.
Randomized prospective clinical study.
Dogs (n = 97).
One hundred consecutive cases (97 dogs) that had clean orthopedic surgery requiring stainless steel plate fixation were randomly assigned using a random number generator to either YES group (administration of postoperative oral antimicrobials) or NO group (no administration of postoperative oral antimicrobials). Dogs in YES group were administered oral cefalexin or potentiated amoxicillin for 7 days, whereas dogs in NO group were discharged without oral antibiotics. Minimum follow-up was 12 months. Multivariable logistic regression was used to determine risk factors for SSI.
Overall postoperative infection rate was 12.9%. Infection occurred in 2 cases (4.3%) administered postoperative oral antimicrobials and in 10 cases (21.3%) not administered postoperative antimicrobials. Total anesthetic time and use of oral antimicrobials were the only significant factors associated with SSI. Use of postoperative antimicrobials was associated with a significant reduction in the risk of infection by ~84% and risk of infection was increased by ~2% for each minute increase in anesthesia time.
Administration of oral postoperative antimicrobials had a protective effect against development of SSI in clean orthopedic implant surgery.
探讨术后口服抗菌药物对涉及不锈钢接骨板系统的清洁骨科手术预防手术部位感染（SSI）是否具有有益作用。
随机前瞻性临床研究。
犬（n = 97）。
连续100例（97只犬）接受需要不锈钢接骨板固定的清洁骨科手术的病例，使用随机数字生成器随机分为“是”组（术后口服抗菌药物）或“否”组（不使用术后口服抗菌药物）。“是”组的犬口服头孢氨苄或增效阿莫西林7天，而“否”组的犬不使用口服抗生素出院。最短随访时间为12个月。采用多变量逻辑回归分析确定SSI的危险因素。
总体术后感染率为12.9%。术后口服抗菌药物的2例（4.3%）发生感染，未使用术后口服抗菌药物的10例（21.3%）发生感染。总麻醉时间和口服抗菌药物的使用是与SSI相关的仅有的显著因素。术后使用抗菌药物使感染风险显著降低约84%，麻醉时间每增加1分钟，感染风险增加约2%。
术后口服抗菌药物对清洁骨科植入手术中SSI的发生具有保护作用。
