Puangpet Pailin, Chawarung Apawalee, McFadden John P
From the *Institute of Dermatology, Bangkok, Thailand; and †St John's Institute of Dermatology, London, United Kingdom.
Dermatitis. 2015 Mar-Apr;26(2):99-102. doi: 10.1097/DER.0000000000000105.
Preservatives used in cosmetics tend to be, by their nature, allergenic. Methylisothiazolinone (MI) has been used as a sole preservative in multiple cosmetics, household goods, and toiletries. A current epidemic of MI has recently been reported in Europe.
The aim of this study was to study the prevalence of methylchloroisothiazolinone/MI (MCI/MI) and MI allergy in a Bangkok dermatology clinic.
During January 2009 to June 2014, 3253 consecutive patients tested with 100 ppm (0.01%) MCI/MI and patients tested with 2000 ppm (0.2%) MI were included in the study.
Three hundred twenty of 3253 patients (9.8%) tested for MCI/MI had a positive reaction. There was a steep increase in the prevalence of MCI/MI contact allergy from 4.8% in 2009 to 11.2% in 2011 and 17% in 2013. In the first 6 months of 2014, 22 of 54 cases tested for MI (40.7%) had a positive reaction. Among those who had a positive reaction to MI, 6 of 22 (27.3%) showed negative reaction to MCI/MI.
There is a similar prevalence of MI allergy in a Bangkok dermatology clinic as those reported in European centers such in the United Kingdom.
化妆品中使用的防腐剂本质上往往具有致敏性。甲基异噻唑啉酮（MI）已被用作多种化妆品、家居用品和洗漱用品的唯一防腐剂。最近欧洲报道了MI的流行情况。
本研究旨在调查曼谷一家皮肤科诊所中甲基氯异噻唑啉酮/甲基异噻唑啉酮（MCI/MI）和MI过敏的患病率。
在2009年1月至2014年6月期间，连续纳入3253例接受100 ppm（0.01%）MCI/MI检测的患者以及接受2000 ppm（0.2%）MI检测的患者。
3253例接受MCI/MI检测的患者中有320例（9.8%）反应呈阳性。MCI/MI接触性过敏的患病率从2009年的4.8%急剧上升至2011年的11.2%，2013年为17%。在2014年的前6个月，54例接受MI检测的患者中有22例（40.7%）反应呈阳性。在对MI反应呈阳性的患者中，22例中有6例（27.3%）对MCI/MI反应呈阴性。
曼谷一家皮肤科诊所中MI过敏的患病率与英国等欧洲中心报道的患病率相似。
