Sakamoto Naotaka, Maki Tomoko, Kobayashi Satoshi, Kobayashi Takeshi, Hamaguchi Masumitsu, Yoshikawa Masahiro, Iguchi Atsushi, Momosaki Seiya, Nakayama Yoshifuku
Nihon Hinyokika Gakkai Zasshi. 2014 Oct;105(4):163-70; discussion 171. doi: 10.5980/jpnjurol.105.163.
The distribution of intraductal carcinoma of the prostate (IDC-P) and other intraductal lesions associated with IDC-P was evaluated in the cancer foci on radical prostatectomy specimens.
We reviewed slide in 412 cases treated by radical prostatectomy without neoadjuvant therapy. Mapping study was performed with regard to IDC-P, other intraductal lesions associated with IDC-P and invasive carcinoma.
We identified 98 cases (23.8%) and 102 cancer foci associated with IDC-P. In these all cancer foci, IDC-P was associated with invasive carcinoma and other intraductal neoplastic lesions with tufting, micropapillary and loose cribriform patterns were contiguous and admixed with IDC-P in 83 cancer foci (81.4%). There were lesions with invasive carcinoma around the IDC-P in 95 cancer foci (93.1%) and lesions without invasive carcinoma around IDC-P in 66 foci (64.7%). The latter lesions existed in the marginal areas of the cancer foci in 63 (61.8%) and in the central areas of the cancer foci in 14 (13.7%). In 5 cancer foci (4.9%), volume of IDC-P was larger than that of invasive carcinoma.
The distribution of IDC-P with dense cribriform and solid patterns varied in cancer foci, and intraductal lesions with tufting, micropapillary and loose cribriform patterns were frequently seen in area contiguous and admixed with IDC-P. The latter lesion may be low grade morphology of IDC-P, although the lesions could not be distinguished from high grade prostatic intraepithelial neoplasia.
在前列腺癌根治术标本的癌灶中评估前列腺导管内癌（IDC-P）及与IDC-P相关的其他导管内病变的分布情况。
我们回顾了412例未经新辅助治疗而行前列腺癌根治术的病例的切片。针对IDC-P、与IDC-P相关的其他导管内病变及浸润性癌进行了定位研究。
我们识别出98例（23.8%）与IDC-P相关的病例及102个癌灶。在所有这些癌灶中，IDC-P与浸润性癌相关，并且83个癌灶（81.4%）中，具有簇状、微乳头状和疏松筛状结构的其他导管内肿瘤性病变与IDC-P相邻并混合存在。95个癌灶（93.1%）中IDC-P周围存在浸润性癌病变，66个癌灶（64.7%）中IDC-P周围不存在浸润性癌病变。后一种病变存在于癌灶边缘区域的有63个（61.8%），存在于癌灶中心区域的有14个（13.7%）。在5个癌灶（4.9%）中，IDC-P的体积大于浸润性癌。
具有致密筛状和实性结构的IDC-P在癌灶中的分布各异，并且在与IDC-P相邻并混合的区域经常可见具有簇状、微乳头状和疏松筛状结构的导管内病变。尽管这些病变无法与高级别前列腺上皮内瘤变区分开来，但后一种病变可能是IDC-P的低级别形态。
