Hu Pingping, Wang Guanghui, Shen Meixiao, Zhang Ping, Zhang Jihong, Du Jiajun, Liu Qi
Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, 324 Jingwu Road, Jinan, PR China.
Future Oncol. 2015;11(5):771-83. doi: 10.2217/fon.14.306.
The role of polymorphonuclear granulocyte (PMN) infiltration in tumor remains unclear in esophageal cancer (EC).
MATERIALS & METHODS: We conducted a retrospective study on consecutive patients with primary squamous EC. The potential roles of PMN infiltration into tumor nests were assessed by immunohistochemistry. The interactions of PMNs and tumor cells were investigated in an in vitro coculture system.
Intratumoral PMN is an independent prognostic factor. PMN infiltration induces epithelial-mesenchymal transition of cancer cells with the initiation of TGF-β/Smad signaling pathway.
Our study demonstrates intratumoral PMN is an independent unfavorable predictor in squamous EC. PMN promotes cancer progression partly by its ability to induce epithelial-mesenchymal transition via TGF-β/Smad signaling pathway.
