帕金森病中纹状体血脑屏障的通透性
Striatal blood-brain barrier permeability in Parkinson's disease.
作者信息
Gray Madison T, Woulfe John M
机构信息
1] Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada [2] Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
1] Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada [2] Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada [3] Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.
出版信息
J Cereb Blood Flow Metab. 2015 May;35(5):747-50. doi: 10.1038/jcbfm.2015.32. Epub 2015 Mar 11.
Abstract
In vivo studies have shown that blood-brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron, and erythrocyte extravasation, we have shown significantly increased permeability of the BBB in the postcommissural putamen of PD patients. The dense innervation of the striatum by PD-affected regions allows for exploitation of this permeability for therapeutic goals. These results are also discussed in the context of the retrograde trans-synaptic hypothesis of PD spread.
摘要
体内研究表明，血脑屏障（BBB）功能障碍与帕金森病（PD）的病程有关。然而，这些研究要么缺乏解剖学定义，要么缺乏识别血脑屏障完整性微小变化的能力。在这里，我们使用血清蛋白、铁和红细胞外渗的组织学标记物，发现PD患者连合后壳核中的血脑屏障通透性显著增加。受PD影响区域对纹状体的密集神经支配使得利用这种通透性实现治疗目标成为可能。我们还在PD传播的逆行跨突触假说的背景下讨论了这些结果。
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