恢复脑屏障：一种治疗神经系统疾病的创新方法。

Restoring brain barriers: an innovative approach for treating neurological disorders.

作者信息

Lemarchant Sighild, Engelhardt Britta, Cicchetti Francesca, Bix Gregory J, Janus Annette, Godfrin Yann, Blasco Hélène, Campbell Matthew, de Rus Jacquet Aurélie

机构信息

Axoltis Pharma, Lyon, 69008, France.

Theodor Kocher Institute, University of Bern, Bern, 3012, Switzerland.

出版信息

Fluids Barriers CNS. 2025 Jul 10;22(1):72. doi: 10.1186/s12987-025-00688-z.

DOI:10.1186/s12987-025-00688-z

PMID:40640916

Abstract

The complex etiology of neurological disorders is a major challenge to the identification of therapeutic candidates. Tackling brain vascular dysfunction is gaining attention from the scientific community, neurologists and pharmaceutical companies, as a novel disease-modifying strategy. Here, we provide evidence that at least 41% of neurological diseases and related conditions/injuries display a co-pathology of blood-brain and blood-spinal cord barrier alterations and dysfunctions, and we discuss why this figure may represent only a fraction of a larger phenomenon. We further provide clinical evidence that barrier status may contribute to pathological and functional outcomes in patients. Finally, we discuss drug candidates under development to repair brain barriers.

摘要

神经系统疾病复杂的病因是确定治疗候选药物的一大挑战。作为一种新的疾病改善策略，解决脑血管功能障碍正受到科学界、神经科医生和制药公司的关注。在此，我们提供证据表明，至少41%的神经系统疾病及相关病症/损伤存在血脑屏障和血脊髓屏障改变及功能障碍的共同病理，并且我们讨论了为何这一数字可能仅代表更大现象的一部分。我们还提供临床证据表明屏障状态可能影响患者的病理和功能结果。最后，我们讨论了正在研发的用于修复脑屏障的候选药物。