Shiota A, Hiramatsu M, Mori A
Department of Neurochemistry, Okayama University Medical School, Japan.
Res Commun Chem Pathol Pharmacol. 1989 Oct;66(1):123-33.
Injection of iron salts into the rodent cortex has been shown to cause chronic or recurrent seizures. Amino acid levels in the cerebral cortex were examined 1, 3, 6, 9, 24, 48 hours and 4 weeks after an injection of ferric chloride solution to the left sensory motor cortex of rats. Aspartate level decreased 9 and 24 hours after the injections with ferric chloride. No significant change was observed in glutamate level, though glutamine level decreased 3 and 48 hours after the injection. GABA level decreased 6 hours after the injection. On the contrary, alanine and glycine levels increased 1 and 24 hours, and 24 hours after the injection, respectively. These results suggest that these amino acid neurotransmitters are involved in the acute seizure mechanism and in the process of chronic focus formation in the iron-induced epilepsy of rats.
已证明向啮齿动物皮层注射铁盐会导致慢性或复发性癫痫发作。在向大鼠左侧感觉运动皮层注射氯化铁溶液后的1、3、6、9、24、48小时以及4周时，检测了大脑皮层中的氨基酸水平。注射氯化铁后9小时和24小时，天冬氨酸水平下降。谷氨酸水平未观察到显著变化，不过注射后3小时和48小时谷氨酰胺水平下降。注射后6小时，γ-氨基丁酸水平下降。相反，丙氨酸和甘氨酸水平分别在注射后1小时和24小时以及24小时后升高。这些结果表明，这些氨基酸神经递质参与了大鼠铁诱导癫痫的急性发作机制和慢性病灶形成过程。
