Kadowaki D, Kinno I, Kadoya K, Mori A, Hiramatsu M
Department of Neuroscience, Okayama University Medical School, Japan.
Res Commun Chem Pathol Pharmacol. 1994 May;84(2):163-73.
Myo-inositol-1,4,5-triphosphoric acid (IP3) formation stimulated by (+-)-1-amino-1,3-cyclopentane-trans-dicarboxylic acid (trans-ACPD) was examined in the cortex, hippocampus and cerebellum of iron-induced epileptic rats and epileptic El mice. Increased IP3 formation by trans-ACPD was observed in the cortex, hippocampus and cerebellum of iron-injected rats while it was found in the hippocampus and cerebellum of the saline-injected control rats. Increased IP3 formation by trans-ACPD was remarkably higher in the hippocampus of iron-injected rats than the other regions. Increased IP3 formation by trans-ACPD was observed in the cortex, hippocampus and cerebellum of ddY mice, while such an increase was found only in the cerebral cortex and not in the hippocampus and cerebellum of El mice. These findings suggest that the inositol response may be involved in the seizure mechanisms of iron-induced epileptic rats and epileptic El mice in some different forms.
在铁诱导的癫痫大鼠和癫痫El小鼠的皮质、海马体和小脑中，研究了（±）-1-氨基-1,3-环戊烷-反式-二羧酸（反式-ACPD）刺激下肌醇-1,4,5-三磷酸（IP3）的形成。在注射铁的大鼠的皮质、海马体和小脑中观察到反式-ACPD导致IP3形成增加，而在注射生理盐水的对照大鼠的海马体和小脑中也发现了这种情况。注射铁的大鼠海马体中反式-ACPD导致的IP3形成增加明显高于其他区域。在ddY小鼠的皮质、海马体和小脑中观察到反式-ACPD导致IP3形成增加，而在El小鼠中，这种增加仅在大脑皮质中发现，在海马体和小脑中未发现。这些发现表明，肌醇反应可能以某些不同形式参与铁诱导的癫痫大鼠和癫痫El小鼠的癫痫发作机制。
