早期帕金森病患者的血小板线粒体活性与农药暴露情况
Platelet mitochondrial activity and pesticide exposure in early Parkinson's disease.
作者信息
Bronstein Jeff M, Paul Kimberly, Yang Laurice, Haas Richard H, Shults Clifford W, Le Thuy, Ritz Beate
机构信息
Department of Neurology, David Geffen School of Medicine, Los Angeles, California, USA.
Greater Los Angeles Veterans Administration Medical Center, Los Angeles, California, USA.
出版信息
Mov Disord. 2015 May;30(6):862-6. doi: 10.1002/mds.26164. Epub 2015 Mar 11.
BACKGROUND
Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD), but the cause of this dysfunction is unclear.
METHODS
Platelet mitochondrial complex I and I/III (nicotinamide adenine dinucleotide cytochrome c reductase, NCCR) activities were measured in early PD patients and matched controls enrolled in a population-based case-control study. Ambient agricultural pesticide exposures were assessed with a geographic information system and California Pesticide Use Registry.
RESULTS
In contrast to some previous reports, we found no differences in complex I and I/III activities in subjects with PD and controls. We did find that NCCR activity correlated with subjects' exposure to pesticides known to inhibit mitochondrial activity regardless of their diagnosis.
CONCLUSIONS
Electron transport chain (ETC) activity is not altered in PD in this well-characterized cohort when compared with community-matched controls but appears to be affected by environmental toxins, such as mitochondria-inhibiting pesticides.
背景
线粒体功能障碍与帕金森病（PD）的发病机制有关，但这种功能障碍的原因尚不清楚。
方法
在一项基于人群的病例对照研究中，对早期PD患者和匹配的对照组进行血小板线粒体复合物I和I/III（烟酰胺腺嘌呤二核苷酸细胞色素c还原酶，NCCR）活性检测。利用地理信息系统和加利福尼亚农药使用登记处评估环境中农业农药暴露情况。
结果
与之前的一些报道不同，我们发现PD患者和对照组的复合物I和I/III活性没有差异。我们确实发现，无论诊断如何，NCCR活性都与受试者接触已知可抑制线粒体活性的农药有关。
结论
与社区匹配的对照组相比，在这个特征明确的队列中，PD患者的电子传递链（ETC）活性没有改变，但似乎受到环境毒素的影响，如抑制线粒体的农药。
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