Department of Epidemiology and Prevention, IRCCS NEUROMED, 86077 Pozzilli, Italy.
Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, University of Leuven, 3000 Leuven, Belgium.
Int J Mol Sci. 2020 Nov 21;21(22):8817. doi: 10.3390/ijms21228817.
Alongside their function in primary haemostasis and thrombo-inflammation, platelets are increasingly considered a bridge between mental, immunological and coagulation-related disorders. This review focuses on the link between platelets and the pathophysiology of major depressive disorder (MDD) and its most frequent comorbidities. Platelet- and neuron-shared proteins involved in MDD are functionally described. Platelet-related studies performed in the context of MDD, cardiovascular disease, and major neurodegenerative, neuropsychiatric and neurodevelopmental disorders are transversally presented from an epidemiological, genetic and functional point of view. To provide a complete scenario, we report the analysis of original data on the epidemiological link between platelets and depression symptoms suggesting moderating and interactive effects of sex on this association. Epidemiological and genetic studies discussed suggest that blood platelets might also be relevant biomarkers of MDD prediction and occurrence in the context of MDD comorbidities. Finally, this review has the ambition to formulate some directives and perspectives for future research on this topic.
除了在初级止血和血栓炎症中的功能外，血小板越来越被认为是精神、免疫和凝血相关疾病之间的桥梁。本综述重点关注血小板与重度抑郁症（MDD）及其最常见合并症的病理生理学之间的联系。本文从流行病学、遗传学和功能的角度，对 MDD、心血管疾病以及主要神经退行性、神经精神和神经发育障碍背景下的血小板相关研究进行了横向介绍。为了提供一个完整的场景，我们报告了对血小板与抑郁症状之间的流行病学联系进行的原始数据分析，结果提示性别对这种关联具有调节和交互作用。讨论的流行病学和遗传学研究表明，血小板也可能是 MDD 预测和发生的生物标志物，尤其是在 MDD 合并症的情况下。最后，本综述旨在为该主题的未来研究制定一些指导方针和展望。
