Mei Mariachiara, Rosen Lauren E, Reddy Vijaya, Cimbaluk David J, Gattuso Paolo
Sapienza University of Rome, Rome, Italy.
Rush University Medical Center, Chicago, IL, USA
Int J Surg Pathol. 2015 Jun;23(4):265-70. doi: 10.1177/1066896915569914. Epub 2015 Mar 10.
Synchronous renal cell neoplasms (RCNs) and angiomyolipomas (AML) occurring in the same kidney are rare. The aim of this retrospective study is to investigate the incidence and clinicopathological features of concurrent AML and RCN in patients without tuberous sclerosis complex (TSC). Partial and radical nephrectomy specimens with a diagnosis of RCN and AML from 1995 to May 2013 were reviewed. Cases were assessed for histological subtype of AML and RCN, topographic relationship between the AML and the RCN, and clinical characteristics. A total of 565 RCNs and 19 AMLs were identified. Of 19 cases of AML, 9 (47%) were associated with renal tumors. Clear-cell renal cell carcinoma (RCC) was the most common malignancy associated with AML (56%). The mean age of patients with concomitant AML and RCN was higher than the mean age of patients with only AML (58.6 vs 55.5 years). The majority of patients with concomitant AML and RCN were female (78%). All concurrent sporadic AMLs were benign. We identified one case of bilateral clear-cell RCC with concomitant multiple bilateral AMLs in a patient with TSC.
同一肾脏中同时发生的肾细胞肿瘤（RCNs）和血管平滑肌脂肪瘤（AML）较为罕见。这项回顾性研究的目的是调查无结节性硬化症（TSC）患者中同时存在AML和RCN的发病率及临床病理特征。回顾了1995年至2013年5月诊断为RCN和AML的部分及根治性肾切除标本。对病例评估了AML和RCN的组织学亚型、AML与RCN之间的位置关系以及临床特征。共识别出565例RCN和19例AML。在19例AML病例中，9例（47%）与肾肿瘤相关。透明细胞肾细胞癌（RCC）是与AML相关的最常见恶性肿瘤（56%）。同时患有AML和RCN的患者的平均年龄高于仅患有AML的患者（58.6岁对55.5岁）。同时患有AML和RCN的患者大多数为女性（78%）。所有同时发生的散发性AML均为良性。我们在一名患有TSC的患者中发现了1例双侧透明细胞RCC同时伴有双侧多发AML的病例。
