Lin Li-Ling, Huang Hsuan-Cheng, Juan Hsueh-Fen
Brief Bioinform. 2015 Nov;16(6):1008-24. doi: 10.1093/bib/bbv006. Epub 2015 Mar 10.
Systems biology, which can be defined as integrative biology, comprises multistage processes that can be used to understand components of complex biological systems of living organisms and provides hierarchical information to decoding life. Using systems biology approaches such as genomics, transcriptomics and proteomics, it is now possible to delineate more complicated interactions between circadian control systems and diseases. The circadian rhythm is a multiscale phenomenon existing within the body that influences numerous physiological activities such as changes in gene expression, protein turnover, metabolism and human behavior. In this review, we describe the relationships between the circadian control system and its related genes or proteins, and circadian rhythm disorders in systems biology studies. To maintain and modulate circadian oscillation, cells possess elaborative feedback loops composed of circadian core proteins that regulate the expression of other genes through their transcriptional activities. The disruption of these rhythms has been reported to be associated with diseases such as arrhythmia, obesity, insulin resistance, carcinogenesis and disruptions in natural oscillations in the control of cell growth. This review demonstrates that lifestyle is considered as a fundamental factor that modifies circadian rhythm, and the development of dysfunctions and diseases could be regulated by an underlying expression network with multiple circadian-associated signals.
系统生物学可被定义为整合生物学，它包含多个阶段的过程，可用于理解生物体复杂生物系统的组成部分，并为解读生命提供层次信息。利用基因组学、转录组学和蛋白质组学等系统生物学方法，现在有可能描绘出昼夜节律控制系统与疾病之间更复杂的相互作用。昼夜节律是一种存在于体内的多尺度现象，它影响着许多生理活动，如基因表达变化、蛋白质周转、新陈代谢和人类行为。在这篇综述中，我们描述了系统生物学研究中昼夜节律控制系统与其相关基因或蛋白质之间的关系，以及昼夜节律紊乱。为了维持和调节昼夜节律振荡，细胞拥有由昼夜节律核心蛋白组成的精细反馈回路，这些蛋白通过其转录活性调节其他基因的表达。据报道，这些节律的破坏与心律失常、肥胖、胰岛素抵抗、致癌作用以及细胞生长控制中自然振荡的破坏等疾病有关。这篇综述表明，生活方式被认为是改变昼夜节律的一个基本因素，功能障碍和疾病的发展可能受具有多个昼夜节律相关信号的潜在表达网络的调节。
