Siciliano M, Barbesino G, Marra L, Milani A, Rossi L
Istituto di Patologia Medica, Università Cattolica S. Cuore, Roma.
Z Gastroenterol. 1989 Nov;27(11):653-6.
The long-term prognostic significance of serum bile acid (SBA) levels in liver cirrhosis was prospectively evaluated in a 3-year follow-up of 111 patients. The predictive value of SBA levels, of Child classification, and of some commonly used clinical and laboratory parameters were compared analyzing the survivorship functions by means of Life-table method and chi-square Logrank test. SBA determinations showed a high prognostic significance, comparable with the one of the multiparameteric Child classification and significantly higher than the ones of any considered single clinical or laboratory parameter. SBA levels by themselves seem therefore to be of some value in establishing an approximate survivorship prediction in liver cirrhosis, thus representing a possible alternative to multiparametric predictive models in routinary clinical practice.
在对111例肝硬化患者进行的3年随访中，前瞻性评估了血清胆汁酸（SBA）水平对肝硬化的长期预后意义。通过寿命表法和卡方对数秩检验分析生存函数，比较了SBA水平、Child分级以及一些常用临床和实验室参数的预测价值。SBA测定显示出较高的预后意义，与多参数Child分级相当，且显著高于任何单个临床或实验室参数。因此，SBA水平本身在建立肝硬化患者大致生存预测方面似乎具有一定价值，从而在常规临床实践中可能成为多参数预测模型的一种替代方法。
