Department of Oral Biology, 614 Salk Hall, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA.
J Pers Med. 2015 Feb 16;5(1):30-5. doi: 10.3390/jpm5010030.
Certain risk factors such as tobacco use, diabetes, genetic variations on the IL1 gene, and other inflammatory conditions are hypothesized to predict tooth loss in patients treated in a large medical center. Tooth loss trends are hypothesized to be greater in patients with more risk factors.
DNA samples for 881 individuals were taken from the Dental Registry and DNA Repository at University of Pittsburgh School of Dental Medicine. Clinical data for all 4137 subjects in the registry were also available. SNP genotyping was performed on the samples for IL1α (rs1800587) and IL1β (rs1143634). IL1 positive status was determined as having one or more of the recessive alleles for either SNP. Tooth loss status was determined based on dental records and data gathered for age, sex, ethnicity, and self-reported medical history. Various statistical analyses were performed on the data including genetic association analysis by the PLINK software, chi-square, Mann-Whitney U, and ANOVA tests to determine significance.
Tooth loss averages increased with age by all risk factors (smoking, diabetes, hypertension, and interleukin genotypes; p = 4.07E-13) and by number of risk factors (p = 0.006). Increased tooth loss is associated with age and number of risk factors including diabetes, tobacco use, IL1+, and cardiovascular disease.
These trends suggest that older patients and those with more risk factors should seek further preventive care to reduce future tooth loss.
某些风险因素，如吸烟、糖尿病、IL1 基因上的遗传变异和其他炎症状况，被假设可以预测在大型医疗中心接受治疗的患者的牙齿缺失。假设具有更多风险因素的患者牙齿缺失趋势更大。
从匹兹堡大学牙医学院的牙科注册处和 DNA 存储库中抽取了 881 个人的 DNA 样本。注册处中所有 4137 名受试者的临床数据也可用。对样本进行了 IL1α(rs1800587)和 IL1β(rs1143634)的 SNP 基因分型。IL1 阳性状态确定为具有一个或多个隐性等位基因的 SNP。根据牙齿记录和年龄、性别、种族和自我报告的病史收集的数据来确定牙齿缺失状态。对数据进行了各种统计分析，包括 PLINK 软件的遗传关联分析、卡方检验、Mann-Whitney U 检验和 ANOVA 检验，以确定显著性。
所有风险因素（吸烟、糖尿病、高血压和白细胞介素基因型；p=4.07E-13）和风险因素数量（p=0.006）都会随着年龄的增长导致牙齿缺失平均值增加。牙齿缺失增加与年龄和包括糖尿病、吸烟、IL1+和心血管疾病在内的多种风险因素有关。
这些趋势表明，年龄较大的患者和具有更多风险因素的患者应寻求进一步的预防保健，以减少未来的牙齿缺失。
