Kugler Christiane, Einhorn Ina, Gottlieb Jens, Warnecke Gregor, Schwarz Anke, Barg-Hock Hannelore, Bara Christoph, Haller Hermann, Haverich Axel
University of Witten, Witten, Germany.
Hannover Medical School, Hannover, Germany.
Prog Transplant. 2015 Mar;25(1):49-55. doi: 10.7182/pit2015668.
Studies of all types of organ transplant recipients have suggested that weight gain, expressed as an increase in body mass index (BMI), after transplant is common.
To describe weight gain during the first year after transplant and to determine risk factors associated with weight gain with particular attention to type of transplant.
DESIGN, SETTING, AND PARTICIPANTS: A prospective study of 502 consecutive organ transplant recipients (261 kidney, 73 liver, 29 heart, 139 lung) to identify patterns of BMI change. Measurements were made during regular outpatient clinical visits at 2, 6, and 12 months after transplant. Data were retrieved from patients' charts and correlated with maintenance corticosteroid doses.
Overall, mean BMI (SD; range) was 23.9 (4.5; 13.6-44.1) at 2 months and increased to 25.4 (4.0; 13.0-42.2) by the end of the first postoperative year. BMI levels organized by World Health Organization categories showed a trend toward overweight/obesity in kidney (53.4%), liver (51.5%), heart (51.7%), and lung (33.1%) patients by 12 months after transplant. BMI changed significantly (P= .05) for all organ types and between all assessment points, except in kidney recipients. Maintenance corticosteroid doses were not a predictor of BMI at 12 months after transplant for most patients.
Weight gain was common among patients undergoing kidney, liver, heart, and lung transplant; however, many showed BMI values close to normality at the end of the first year after transplant. In most cases, increased BMI levels were related to obesity before transplant and not to maintenance corticosteroid therapy.
对各类器官移植受者的研究表明，移植后体重增加（以体重指数（BMI）升高表示）很常见。
描述移植后第一年的体重增加情况，并确定与体重增加相关的危险因素，尤其关注移植类型。
设计、地点和参与者：一项对502例连续器官移植受者（261例肾移植、73例肝移植、29例心脏移植、139例肺移植）的前瞻性研究，以确定BMI变化模式。在移植后2、6和12个月的定期门诊临床就诊时进行测量。数据从患者病历中获取，并与维持性皮质类固醇剂量相关联。
总体而言，2个月时平均BMI（标准差；范围）为23.9（4.5；13.6 - 44.1），术后第一年末增至25.4（4.0；13.0 - 42.2）。按世界卫生组织分类组织的BMI水平显示，肾移植（53.4%）、肝移植（51.5%）、心脏移植（51.7%）和肺移植（33.1%）患者在移植后12个月时有超重/肥胖趋势。除肾移植受者外，所有器官类型在所有评估点之间的BMI均有显著变化（P = .05）。对于大多数患者，移植后12个月时维持性皮质类固醇剂量不是BMI的预测指标。
肾、肝、心脏和肺移植患者体重增加很常见；然而，许多患者在移植后第一年末的BMI值接近正常。在大多数情况下，BMI水平升高与移植前肥胖有关，而非与维持性皮质类固醇治疗有关。
