Beckmann Sonja, Nikolic Nataša, Denhaerynck Kris, Binet Isabelle, Koller Michael, Boely Elsa, De Geest Sabina
Institute of Nursing Science, University of Basel, Basel, Switzerland.
Department of Abdomen-Metabolism, University Hospital Zurich, Zurich, Switzerland.
Clin Transplant. 2017 Mar;31(3). doi: 10.1111/ctr.12896. Epub 2017 Jan 24.
Obesity and weight gain are serious concerns after solid organ transplantation (Tx); however, no unbiased comparison regarding body weight parameter evolution across organ groups has yet been performed. Using data from the prospective nationwide Swiss Transplant Cohort Study, we compared the evolution of weight parameters up to 3 years post-Tx in 1359 adult kidney (58.3%), liver (21.7%), lung (11.6%), and heart (8.4%) recipients transplanted between May 2008 and May 2012. Changes in mean weight and body mass index (BMI) category were compared to reference values from 6 months post-Tx. At 3 years post-Tx, compared to other organ groups, liver Tx recipients showed the greatest weight gain (mean 4.8±10.4 kg), 57.4% gained >5% body weight, and they had the highest incidence of obesity (38.1%). After 3 years, based on their BMI categories at 6 months, normal weight and obese liver Tx patients, as well as underweight kidney, lung and heart Tx patients had the highest weight gains. Judged against international Tx patient data, the majority of our Swiss Tx recipients' experienced lower post-Tx weight gain. However, our findings show weight gain pattern differences, both within and across organ Tx groups that call for preventive measures.
肥胖和体重增加是实体器官移植（Tx）后令人严重关切的问题；然而，尚未对各器官组间体重参数的演变进行无偏倚比较。利用来自瑞士全国前瞻性移植队列研究的数据，我们比较了2008年5月至2012年5月间接受移植的1359例成年肾移植受者（58.3%）、肝移植受者（21.7%）、肺移植受者（11.6%）和心脏移植受者（8.4%）移植后3年内体重参数的演变情况。将平均体重和体重指数（BMI）类别的变化与移植后6个月的参考值进行比较。移植后3年，与其他器官组相比，肝移植受者体重增加最多（平均4.8±10.4kg），57.4% 的受者体重增加超过5%，且肥胖发生率最高（38.1%）。3年后，根据6个月时的BMI类别，体重正常和肥胖的肝移植患者，以及体重过轻的肾、肺和心脏移植患者体重增加最多。与国际移植患者数据相比，我们瑞士大多数移植受者移植后的体重增加较低。然而，我们的研究结果显示，器官移植组内和组间的体重增加模式存在差异，这需要采取预防措施。
