Atladóttir H Ó, Schendel D E, Parner E T, Henriksen T B
Section of Epidemiology, Department of Public Health, Aarhus University, Barthooins Alle 2, Aarhus C, 8000, Århus, Denmark,
J Autism Dev Disord. 2015 Aug;45(8):2429-42. doi: 10.1007/s10803-015-2408-7.
The aim of this study was to describe the profile of specific neonatal morbidities in children later diagnosed with autism spectrum disorder (ASD), and to compare this profile with the profile of children with hyperkinetic disorder, cerebral palsy, epilepsy or intellectual disability. This is a Danish population based cohort study, including all children born in Denmark from 1994, through 2010, and surviving the first year of life. Children with ASD as a whole have significantly elevated rates of a range of neurologic, respiratory, inflammatory, and metabolic problems in the neonatal period compared to the general population, but there are few if any indicators of a distinctive neonatal morbidity profile in ASD compared to other neurodevelopmental outcomes.
本研究的目的是描述后来被诊断为自闭症谱系障碍（ASD）的儿童的特定新生儿疾病概况，并将此概况与患有多动障碍、脑瘫、癫痫或智力残疾的儿童的概况进行比较。这是一项基于丹麦人群的队列研究，包括1994年至2010年在丹麦出生且存活至一岁的所有儿童。与普通人群相比，ASD儿童总体上在新生儿期出现一系列神经、呼吸、炎症和代谢问题的发生率显著升高，但与其他神经发育结果相比，几乎没有任何ASD独特的新生儿疾病概况指标。
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