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社区学龄前自闭症儿童:发展概况。

Autism in community pre-schoolers: developmental profiles.

机构信息

Gillberg Neuropsychiatry Centre, Sahlgrenska Academy, University of Gothenburg, Sweden.

出版信息

Res Dev Disabil. 2013 Sep;34(9):2900-8. doi: 10.1016/j.ridd.2013.06.016. Epub 2013 Jun 28.

Abstract

Autism is often a complex developmental disorder. The aim of the present study was to describe the developmental characteristics of 129 1-4-year-old children (102 boys, 27 girls) referred for clinical assessment (mean age 2.9 years) due to suspicion of autism spectrum disorder (ASD) after community screening at Child Health Care centers. All children were clinically assessed at the Child Neuropsychiatry Clinic (CNC) in Gothenburg by a research team (neurodevelopmental examination, structured interviews and general cognitive and language examinations). Of the 129 children, 100 met diagnostic criteria for ASD (69 with autistic disorder, and 31 with atypical autism/pervasive developmental disorder-not otherwise specified). The remaining 29 children had a variety of developmental disorders, most often attention-deficit/hyperactivity disorder (ADHD), language disorder, borderline intellectual functioning, and intellectual developmental disorder (IDD) with (n=25) or without (n=4) autistic traits (AT). IDD was found in 36% of the 100 children with ASD, and in 4% of the 25 children with AT. Of the children with ASD, 56% had language disorder with no or just a few words at the initial assessment at the CNC, many of whom in combination with IDD. Hyperactivity was found in 37% of those with ASD and in 40% of those with AT. Epilepsy was found in 6% of the total group and in 7% of those with a diagnosis of ASD. Of the latter group 11% had a history of regression, while none of the AT cases had a similar background. When results were compared with a non-screened preschool ASD group of 208 children, referred for ASD intervention at a mean age of 3.4 years, very similar developmental profiles were seen. In conclusion, early community ASD screening appears to systematically identify those children who are in need of intervention and follow-up.

摘要

自闭症通常是一种复杂的发育障碍。本研究的目的是描述 129 名 1-4 岁儿童(102 名男孩,27 名女孩)的发育特征,这些儿童因社区保健中心筛查后怀疑患有自闭症谱系障碍(ASD)而接受临床评估(平均年龄 2.9 岁)。所有儿童均由哥德堡儿童神经精神病学诊所(CNC)的研究团队进行临床评估(神经发育检查、结构化访谈和一般认知及语言检查)。在 129 名儿童中,有 100 名符合 ASD 的诊断标准(69 名患有自闭症,31 名患有非典型自闭症/广泛性发育障碍-未特定)。其余 29 名儿童患有各种发育障碍,最常见的是注意缺陷多动障碍(ADHD)、语言障碍、边缘智力功能和伴有(n=25)或不伴有(n=4)自闭症特征(AT)的智力发育障碍(IDD)。在 100 名 ASD 儿童中发现了 36%的 IDD,在 25 名 AT 儿童中发现了 4%的 IDD。在 ASD 儿童中,56%的儿童在 CNC 的初始评估中存在语言障碍,仅有少数词汇,其中许多儿童还伴有 IDD。在 ASD 儿童中发现了 37%的多动,在 AT 儿童中发现了 40%的多动。在总人群中发现了 6%的癫痫,在 ASD 诊断组中发现了 7%的癫痫。在后者中,有 11%的儿童有倒退史,而在 AT 病例中没有类似的背景。将结果与一个由 208 名儿童组成的非筛查性学龄前 ASD 组进行比较,这些儿童在平均年龄为 3.4 岁时因 ASD 干预而被转诊,发现非常相似的发育特征。总之,早期的社区 ASD 筛查似乎能够系统地识别出那些需要干预和随访的儿童。

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