Youssef Doaa Mohammed, Tawfek Doaa Mostafa, Mohammed Abdelsalam Mohammed, Mohammed Rania, Khalifa Naglaa Ahmed
Department of Pediatric Nephrology, Zagazig University, Zagazig, Egypt.
Saudi J Kidney Dis Transpl. 2015 Mar;26(2):314-9. doi: 10.4103/1319-2442.152493.
Clinical manifestations of systemic lupus erythematosus (SLE) are widely variable, and its course is unpredictable. SLE that begins in childhood has been considered more severe than SLE with onset during adulthood. Our aim was to determine the presentation and the outcome of SLE of 26 children (20 females and 6 males, with a female to male ratio of 3.8:1) with SLE in our center, their ages ranging from 5 - 18 years and followed from 2005 till October 2011. They were diagnosed according to the American Rheumatism Association's revised criteria. Complete blood count, erythrocyte sedimentation rate, C3, urine analysis, 24-h urinary protein, antinuclear antibodies, anti-ds DNA and renal biopsy were obtained for the patients. We found that the most extra-renal manifestation of SLE was fever (57.7%), while lupus nephritis (LN) was the most commonly affected organ (50%). Hemolytic anemia was the most common hematological abnormality (80.8%), while immunological characteristics were positive in all the patients. Remission in patients without LN was more than 5.3-times the remission in LN patients. The outcome of the patients without LN was better than the patients with LN.
系统性红斑狼疮（SLE）的临床表现广泛多样，其病程不可预测。儿童期起病的SLE被认为比成年期起病的SLE更为严重。我们的目的是确定在我们中心的26例SLE患儿（20例女性，6例男性，男女比例为3.8:1）的临床表现及预后，他们的年龄在5至18岁之间，随访时间从2005年至2011年10月。他们根据美国风湿病学会修订的标准进行诊断。为患者进行了全血细胞计数、红细胞沉降率、C3、尿液分析、24小时尿蛋白、抗核抗体、抗双链DNA及肾活检。我们发现SLE最常见的肾外表现是发热（57.7%），而狼疮性肾炎（LN）是最常受累的器官（50%）。溶血性贫血是最常见的血液学异常（80.8%），而所有患者的免疫学特征均为阳性。无LN患者的缓解率是LN患者缓解率的5.3倍以上。无LN患者的预后优于有LN的患者。
