Ashournia Parisa, Sadeghi Payman, Rezaei Nima, Moradinejad Mohammad-Hassan, Ziaee Vahid
Children's Medical Center, Pediatrics Center of Excellence, Tehran, Iran.
Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.
Maedica (Bucur). 2018 Mar;13(1):21-24.
One of the causes of infants' hospitalizations is bronchiolitis, while different viral agents could be causative agents. As there is little information regarding the common agents of bronchiolitis in Iranian infants, we designed this study to determine which agents were responsible for hospitalization due to bronchiolitis among infants in an Iranian tertiary center. Two hundred and three infants with bronchiolitis who were hospitalized in Bahrami hospital were enrolled. Data regarding age, sex, duration of hospitalization, exposure to smoking, previous antibiotic usage and fever were collected for all enrolled cases. Throat sample by means of soap was collected and rapid test with immunochromatography (IC) test was performed. Rapid test was positive in 59 (29%) cases and three cases had concomitant infection with two viruses. The most common viral agent was RSV (Respiratory Syncytial Virus). Mean age was significantly lower in cases with RSV or RSV+ adenovirus infectious in comparison with other two groups (adenovirus or influenza only), while mean duration of hospitalization was significantly longer in RSV/RSV+ adenovirus group. RSV is the most common viral etiology of bronchiolitis in Iranian infants less than one year old, which is related with younger age and longer duration of hospitalization. Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Near 10% of affected children have a relative with SLE. Autoimmune diseases are more common in relatives of children with SLE. As there is no study regarding the prevalence of autoimmune disease in cases with pediatric SLE, we designed this study to evaluate the prevalence of autoimmune disease in children with SLE. In this cross sectional study, 50 children with SLE and 50 healthy children were enrolled. A structured questionnaire was used to collect data regarding the presence of autoimmune diseases in relatives. One thousand eight hundred and thirty two relatives were evaluated in the case group and 1699 in the control group. The number of relatives with autoimmune diseases was significantly higher in the case group (26 vs 10). The most common autoimmune diseases were lupus, followed by thyroid diseases among cases, and thyroid diseases and rheumatoid arthritis in controls. According to the results of this study, the prevalence of autoimmune disorders is more common in relatives of children with SLE than in those of controls.
婴儿住院的原因之一是细支气管炎，而不同的病毒病原体可能是致病因素。由于关于伊朗婴儿细支气管炎常见病原体的信息较少，我们设计了这项研究，以确定在伊朗一家三级医疗中心中，哪些病原体导致婴儿因细支气管炎住院。纳入了203名在巴赫拉米医院住院的细支气管炎婴儿。收集了所有纳入病例的年龄、性别、住院时间、接触吸烟情况、既往抗生素使用情况和发热情况等数据。通过肥皂采集咽拭子样本，并进行免疫层析（IC）快速检测。59例（29%）快速检测呈阳性，3例同时感染两种病毒。最常见的病毒病原体是呼吸道合胞病毒（RSV）。与其他两组（仅腺病毒或流感病毒感染组）相比，RSV或RSV+腺病毒感染病例的平均年龄显著更低，而RSV/RSV+腺病毒组的平均住院时间显著更长。RSV是伊朗1岁以下婴儿细支气管炎最常见的病毒病因，这与年龄较小和住院时间较长有关。系统性红斑狼疮（SLE）是一种多系统自身免疫性疾病。近10%的患病儿童有亲属患SLE。自身免疫性疾病在SLE患儿的亲属中更为常见。由于尚无关于儿童SLE病例中自身免疫性疾病患病率的研究，我们设计了这项研究来评估SLE患儿中自身免疫性疾病的患病率。在这项横断面研究中，纳入了50名SLE患儿和50名健康儿童。使用结构化问卷收集关于亲属中自身免疫性疾病存在情况的数据。病例组评估了1832名亲属，对照组评估了1699名亲属。病例组中患有自身免疫性疾病的亲属数量显著高于对照组（26例对10例）。病例组中最常见的自身免疫性疾病是狼疮，其次是甲状腺疾病；对照组中是甲状腺疾病和类风湿关节炎。根据这项研究的结果，SLE患儿亲属中自身免疫性疾病的患病率高于对照组亲属。
