两种大鼠品系纹状体中假定的快突触中间神经元的不同特性。

Differing properties of putative fast-spiking interneurons in the striatum of two rat strains.

作者信息

Perk C G, Wickens J R, Hyland B I

机构信息

Department of Physiology, Otago School of Medical Sciences, Brain Health Research Centre, and Brain Research New Zealand, University of Otago, Dunedin 9054, New Zealand; Department of Anatomy, Otago School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand.

Department of Anatomy, Otago School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand; Neurobiology Research Unit, Okinawa Institute of Science and Technology, 1919-1, Tancha, Onna-Son, Kunigami, Okinawa 904-0412, Japan.

出版信息

Neuroscience. 2015 May 21;294:215-26. doi: 10.1016/j.neuroscience.2015.02.051. Epub 2015 Mar 7.

DOI:10.1016/j.neuroscience.2015.02.051

PMID:25758937

Abstract

Local circuits within the striatum of the basal ganglia include a small number of γ-aminobutyric acid (GABA)-ergic fast-spiking interneurons (FSI). The number of these cells is reduced in disorders of behavioral control, but it is unknown whether this is accompanied by altered electrophysiological properties. The genetically hypertensive (GH) rat strain exhibits impulsiveness and hyperactivity. We investigated if resting-state FSI activity is affected in this strain using extracellular recordings. We also examined the effect of systemic amphetamine (AMPH), a stimulant drug used in the treatment of these particular behavioral deficits. Putative FSI (pFSI) were encountered less often in GH rats compared to the Wistar control strain. pFSI in GH rats also exhibited a higher mean firing rate, higher intraburst firing rate, lower interburst interval, and shorter bursts compared to controls. AMPH increased the mean overall firing rate of Wistar rat pFSI but did not significantly alter the firing properties of this subtype in GH rats. These differences in the resting-state electrophysiological activity of pFSI in GH rats point to them as a cell type of particular interest in understanding striatal functioning across different strains.

摘要

基底神经节纹状体内的局部回路包含少量γ-氨基丁酸（GABA）能快速发放中间神经元（FSI）。在行为控制障碍中，这些细胞的数量会减少，但尚不清楚这是否伴随着电生理特性的改变。遗传性高血压（GH）大鼠品系表现出冲动和多动。我们使用细胞外记录来研究该品系静息状态下FSI的活动是否受到影响。我们还研究了全身性苯丙胺（AMPH）的作用，苯丙胺是一种用于治疗这些特定行为缺陷的兴奋剂药物。与Wistar对照品系相比，在GH大鼠中遇到假定的FSI（pFSI）的频率较低。与对照组相比，GH大鼠中的pFSI还表现出更高的平均发放率、更高的爆发内发放率、更低的爆发间隔和更短的爆发。AMPH增加了Wistar大鼠pFSI的平均总体发放率，但并未显著改变GH大鼠中该亚型的发放特性。GH大鼠中pFSI静息状态电生理活动的这些差异表明，它们是理解不同品系纹状体功能时特别值得关注的一种细胞类型。