Caamaño G J, Sánchez-del-Castillo M A, Iglesias J, García-Peregrín E, Linares A
Departamento de Bioquímica y Biología Molecular, Universidad de Granada, Spain.
Biochem Int. 1989 Oct;19(4):855-61.
The effect of fasting and refeeding on oxidation, lipogenesis and amino acid synthesis from ketone bodies has been studied in neonatal chick duodenal mucosa. Oxidation and amino acid synthesis were higher from acetoacetate and were stimulated by fasting from both 3-hydroxybutyrate and acetoacetate. On the contrary, lipogenesis was always higher from 3-hydroxybutyrate and fasting reduced lipogenesis rate from acetoacetate (by 66%) but not from 3-hydroxybutyrate. Results suggests the existence of a cytosolic fast-dependent acetoacetyl-CoA synthetase in chick duodenal mucosa which is involved in phospholipid synthesis.
禁食和再喂养对新生雏鸡十二指肠黏膜中酮体氧化、脂肪生成及氨基酸合成的影响已得到研究。乙酰乙酸的氧化和氨基酸合成较高，禁食会刺激3-羟基丁酸和乙酰乙酸的氧化及氨基酸合成。相反，3-羟基丁酸的脂肪生成始终较高，禁食降低了乙酰乙酸的脂肪生成速率（降低66%），但未降低3-羟基丁酸的脂肪生成速率。结果表明，雏鸡十二指肠黏膜中存在一种依赖于禁食的胞质乙酰乙酰辅酶A合成酶，其参与磷脂合成。
