Schotter A, Müller R, Günther C, Hausleiter H J, Achtert G
Klinikum Hof/Saale, Fed. Rep. of Germany.
Arzneimittelforschung. 1989 Nov;39(11):1468-70.
Ten young women took part in this study a few days after delivery (day 3 and day 5 post partum). Lactation had developed normally but the newborn infants were not breast-fed. The study was intended to investigate whether metaclazepam (Talis), a new 1,4-benzodiazepine, and some of its metabolites were present in breast milk. Levels were measured in the plasma and milk. The levels in the milk showed that metaclazepam, N-desmethylmetaclazepam and two of its metabolites with a lactam structure could be found in small amounts. Differences in metaclazepam and N-desmethylmetaclazepam concentrations in the breast milk on days 3 and 5 post partum are discussed.
十名年轻女性在分娩后几天（产后第3天和第5天）参与了这项研究。泌乳情况正常，但新生儿未进行母乳喂养。该研究旨在调查新型1,4 - 苯二氮䓬类药物美他氯氮平（Talis）及其某些代谢产物是否存在于母乳中。对血浆和母乳中的含量进行了测量。母乳中的含量显示，可发现少量的美他氯氮平、N - 去甲基美他氯氮平及其两种具有内酰胺结构的代谢产物。讨论了产后第3天和第5天母乳中美他氯氮平和N - 去甲基美他氯氮平浓度的差异。
