[甲状腺自身免疫与内分泌性突眼症研究的个人经验]

[Personal experience in the study of thyroid autoimmunity and endocrine exophthalmos].

作者信息

Winand R

出版信息

Bull Mem Acad R Med Belg. 1989;144(5-7):363-70; discussion 370-2.

Abstract

Most of the thyroid disorders are considered as being autoimmune diseases. It is the case for autoimmune thyroiditis where various antibodies are found. In Graves' Basedow disease, one or several immunoglobulin(s) which stimulate(s) the thyroid were found. In simple goitre, autoimmune origin is probable. We have measured the presence of anti-alpha-galactosyl antibody in various thyroid disorders. An increase titre was observed in progressive Graves' ophthalmopathy, untreated Graves' disease, progressive simple goitres and in autoimmune thyroiditis. Therefore, we think that the measure of anti-alpha-galactosyl antibodies represents reproducible parameter in order to know if the thyroid disease is or not in progression.

摘要

大多数甲状腺疾病被认为是自身免疫性疾病。自身免疫性甲状腺炎就是这种情况，在其中发现了各种抗体。在格雷夫斯病（突眼性甲状腺肿）中，发现了一种或几种刺激甲状腺的免疫球蛋白。在单纯性甲状腺肿中，很可能起源于自身免疫。我们已经检测了各种甲状腺疾病中抗α-半乳糖基抗体的存在情况。在进行性格雷夫斯眼病、未经治疗的格雷夫斯病、进行性单纯性甲状腺肿和自身免疫性甲状腺炎中观察到滴度升高。因此，我们认为抗α-半乳糖基抗体的检测是一个可重复的参数，用于了解甲状腺疾病是否处于进展期。