Department of Medicine, Surgery and Neurosciences, Unit of General Surgery and Surgical Oncology, University of Siena, Policlinico "Le Scotte", Viale Bracci, 53100 Siena, Italy.
Department of Medicine, Surgery and Neurosciences, Unit of General and Mini-Invasive Surgery, University of Siena, Policlinico "Le Scotte", Viale Bracci, 53100 Siena, Italy.
Gastroenterol Res Pract. 2015;2015:810134. doi: 10.1155/2015/810134. Epub 2015 Feb 10.
Introduction. The impact of preoperative BMI on surgical outcomes and long-term survival of gastric cancer patients was investigated in various reports with contrasting results. Materials & Methods. A total of 378 patients who underwent a surgical resection for primary gastric cancer between 1994 and 2011 were retrospectively studied. Patients were stratified according to BMI into a normal group (<25, group A), an overweight group (25-30, group B), and an obesity group (≥30, group C). These 3 groups were compared according to clinical-pathological characteristics, surgical treatment, and long-term survival. Results. No significant correlations between BMI and TNM (2010), UICC stage (2010), Lauren's histological type, surgical results, lymph node dissection, and postoperative morbidity and mortality were observed. Factors related to higher BMI were male gender (P < 0.05), diabetes (P < 0.001), and serum blood proteins (P < 0.01). A trend to fewer lymph nodes retrieved during gastrectomy with lymphadenectomy in overweight patients (B and C groups) was observed, although not statistically significant. There was no difference in overall survival or disease-specific survival between the three groups. Conclusion. According to our data, BMI should not be considered a significant predictor of postoperative complications or long-term result in gastric cancer patients.
简介。术前 BMI 对胃癌患者手术结果和长期生存的影响在各种报告中进行了研究，结果相互矛盾。材料与方法。回顾性研究了 1994 年至 2011 年间接受原发性胃癌手术切除的 378 例患者。根据 BMI 将患者分为正常组（<25，A 组）、超重组（25-30，B 组）和肥胖组（≥30，C 组）。根据临床病理特征、手术治疗和长期生存情况对这 3 组进行比较。结果。BMI 与 TNM（2010）、UICC 分期（2010）、Lauren 组织学类型、手术结果、淋巴结清扫术以及术后发病率和死亡率之间无显著相关性。与较高 BMI 相关的因素是男性（P < 0.05）、糖尿病（P < 0.001）和血清蛋白（P < 0.01）。超重患者（B 组和 C 组）在接受胃癌根治术和淋巴结清扫术时，淋巴结检出数呈减少趋势，但无统计学意义。三组之间的总生存率或疾病特异性生存率无差异。结论。根据我们的数据，BMI 不应被视为胃癌患者术后并发症或长期结果的重要预测因素。
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