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移植人脐带间充质干细胞促进 B6.Fas 小鼠的病灶修复。

Transplanted human umbilical cord mesenchymal stem cells facilitate lesion repair in B6.Fas mice.

机构信息

Stem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China.

Kunming Biological Diversity Regional Center of Large Apparatus and Equipment, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.

出版信息

J Immunol Res. 2014;2014:530501. doi: 10.1155/2014/530501. Epub 2014 Dec 29.

DOI:10.1155/2014/530501
PMID:25759830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4352485/
Abstract

BACKGROUND

Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists.

METHODS

We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice.

RESULTS

After four rounds of cell transplantation, we observed a statistically significant decrease in the levels of mouse anti-nuclear, anti-histone, and anti-double-stranded DNA antibodies in transplanted mice compared with controls. The percentage of CD4(+)CD25(+)Foxp3(+) T cells in mouse peripheral blood significantly increased after H-UC-MSC transplantation.

CONCLUSIONS

The results showed that H-UC-MSCs could repair lesions in B6.Fas mice such that all of the relevant disease indicators in B6.Fas mice were restored to the levels observed in normal C57BL/6 mice.

摘要

背景

系统性红斑狼疮（SLE）是一种多系统疾病，其特征是出现血清自身抗体。目前尚无 SLE 的有效治疗方法。

方法

我们使用人脐带间充质干细胞（H-UC-MSC）移植来治疗 B6.Fas 小鼠。

结果

经过四轮细胞移植后，与对照组相比，我们观察到移植小鼠的鼠抗核、抗组蛋白和抗双链 DNA 抗体水平有统计学意义的下降。H-UC-MSC 移植后，小鼠外周血中 CD4(+)CD25(+)Foxp3(+)T 细胞的百分比显著增加。

结论

结果表明，H-UC-MSCs 可修复 B6.Fas 小鼠的损伤，使 B6.Fas 小鼠的所有相关疾病指标均恢复到正常 C57BL/6 小鼠的水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c2/4352485/027ecbdefde1/JIR2014-530501.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c2/4352485/3dc455a4d397/JIR2014-530501.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c2/4352485/d9a2b0da44ac/JIR2014-530501.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c2/4352485/f226f6144d1b/JIR2014-530501.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c2/4352485/53d0e869bb5f/JIR2014-530501.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c2/4352485/da5f8d1bde20/JIR2014-530501.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c2/4352485/20a6acccbe49/JIR2014-530501.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c2/4352485/027ecbdefde1/JIR2014-530501.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c2/4352485/3dc455a4d397/JIR2014-530501.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c2/4352485/d9a2b0da44ac/JIR2014-530501.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c2/4352485/f226f6144d1b/JIR2014-530501.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c2/4352485/53d0e869bb5f/JIR2014-530501.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c2/4352485/da5f8d1bde20/JIR2014-530501.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c2/4352485/20a6acccbe49/JIR2014-530501.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c2/4352485/027ecbdefde1/JIR2014-530501.007.jpg

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