加利福尼亚教师研究队列中的饮食模式与子宫内膜癌风险
Dietary patterns and endometrial cancer risk in the California Teachers Study cohort.
作者信息
Canchola Alison J, Lacey James V, Bernstein Leslie, Horn-Ross Pamela L
机构信息
Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA, 94538, USA,
出版信息
Cancer Causes Control. 2015 Apr;26(4):627-34. doi: 10.1007/s10552-015-0552-1. Epub 2015 Mar 12.
PURPOSE
Information on the role of dietary patterns and endometrial cancer risk is limited. We investigated whether dietary patterns are associated with endometrial cancer risk among women in the California Teachers Study cohort.
METHODS
Among 75,093 eligible women, 937 developed invasive endometrial cancer between 1995 and 2011. Multivariate Cox regression was performed to estimate relative risks (RR) and 95% confidence intervals (CI) associated with five dietary patterns identified by principal components factor analysis: "plant-based," "high protein/high fat," "high carbohydrates," "ethnic," and "salad and wine."
RESULTS
These dietary patterns were not associated with endometrial cancer risk overall (RR = 0.91, 95% CI: 0.72, 1.15 for the highest vs. lowest quintile of the "plant-based" dietary pattern) or by menopausal status and hormone therapy use.
CONCLUSIONS
Dietary patterns do not seem to be associated with endometrial cancer risk.
目的
关于饮食模式与子宫内膜癌风险之间关系的信息有限。我们在加利福尼亚教师研究队列中调查了饮食模式是否与女性子宫内膜癌风险相关。
方法
在75093名符合条件的女性中，有937人在1995年至2011年间患浸润性子宫内膜癌。采用多变量Cox回归分析来估计与通过主成分因子分析确定的五种饮食模式相关的相对风险（RR）和95%置信区间（CI），这五种饮食模式分别为：“植物性”、“高蛋白/高脂肪”、“高碳水化合物”、“民族特色”和“沙拉与葡萄酒”。
结果
总体而言，这些饮食模式与子宫内膜癌风险无关（“植物性”饮食模式最高五分位数与最低五分位数相比，RR = 0.91，95% CI：0.72，1.15），按绝经状态和激素治疗使用情况分析也是如此。
结论
饮食模式似乎与子宫内膜癌风险无关。
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