Bolognini D, Ross R A
Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada.
Wolfson Link Bldg. 253, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.
Clin Pharmacol Ther. 2015 Jun;97(6):568-70. doi: 10.1002/cpt.107. Epub 2015 May 9.
The medical use of cannabis has an intricate therapeutic history that finds its roots in ancient China (∼2700 BC). The main psychoactive component of cannabis, Δ(9) -tetrahydrocannabinol (Δ(9) -THC), was discovered in 1964. This was a significant breakthrough, as it allowed the generation of synthetic analogs of Δ(9) -THC, the discovery of cannabinoid receptors, and the generation of synthetic small molecules. Despite this, today there is still a paucity of drugs that target the cannabinoid system.
大麻的医学用途有着复杂的治疗历史，其根源可追溯到古代中国（约公元前2700年）。大麻的主要精神活性成分Δ(9)-四氢大麻酚（Δ(9)-THC）于1964年被发现。这是一项重大突破，因为它使得Δ(9)-THC的合成类似物得以产生、大麻素受体被发现以及合成小分子得以生成。尽管如此，如今针对大麻素系统的药物仍然匮乏。
