Strout C D, Nahrwold M L, Taylor M G, Zagon I S
Environ Health Perspect. 1977 Dec;21:211-4. doi: 10.1289/ehp.7721211.
Anesthetic pollutants in the operating room have been implicated in producing spontaneous abortion in exposed personnel and congenital malformations among their offspring. To test the effects of trace concentrations of enflurane on pregnancy, rats were exposed to two levels (10.7 and 63.7 ppm) of the anesthetic for 8 hr daily from days 1 to 19 of pregnancy. Litter sizes were not affected but birth weights of exposed offspring were slightly higher than controls. During lactation, cross-fostering studies were performed. Exposed offspring were housed with nonexposed mothers and vice versa to determine if exposure during pregnancy affected early development. Weights at 7, 14, and 21 days of age did not differ among the offspring in the lower dose experiment. Weights of the cross-fostered groups in the high dose experiment were decreased at day seven compared to controls. In the same experiment, exposed offspring housed with exposed mothers were heavier than controls on day 21 of lactation. The modest nature of these alterations suggests that enflurane has little or no gross effect on rat pregnancy and postnatal development.
手术室中的麻醉污染物被认为会导致接触者自然流产，并使其后代出现先天性畸形。为了测试微量安氟醚对妊娠的影响，在妊娠第1天至第19天，将大鼠每天暴露于两种浓度（10.7 ppm和63.7 ppm）的该麻醉剂中8小时。窝仔数未受影响，但暴露组后代的出生体重略高于对照组。在哺乳期进行了交叉寄养研究。将暴露组后代与未暴露组母亲饲养在一起，反之亦然，以确定孕期暴露是否会影响早期发育。在低剂量实验中，7日龄、14日龄和21日龄后代的体重没有差异。在高剂量实验中，与对照组相比，交叉寄养组在第7天体重下降。在同一实验中，在哺乳期第21天，与暴露组母亲饲养在一起的暴露组后代比对照组重。这些变化程度较小，表明安氟醚对大鼠妊娠和产后发育几乎没有明显影响。
