Speroff L
Oregon Health Sciences, University School of Medicine, Portland.
Int J Fertil. 1989;34 Suppl:34-9.
Early reports linking the use of contraceptive steroids to congenital malformations have not been substantiated. There is a delay in the return of fertility after cessation of oral contraceptive use, but this may be concentrated in childless women aged 30 to 34. Oral contraception does not influence the rate of infertility. After the cessation of oral contraceptive use, there is no increase in the incidence of spontaneous abortion in subsequent pregnancies, nor is there an increased risk of pregnancy complications. Women who use oral contraceptives do not breast-feed as long as nonusers, but no differences can be detected between the growth and development of the children of oral contraceptive users and nonusers. There is no relationship between oral contraceptive use and pituitary adenomas, or between oral contraceptive use and subsequent amenorrhea.
早期有关使用避孕甾体激素与先天性畸形之间关联的报告尚未得到证实。停用口服避孕药后生育能力恢复会有所延迟,但这种情况可能集中在30至34岁未育女性中。口服避孕药不会影响不孕率。停用口服避孕药后,后续妊娠中自然流产的发生率不会增加,妊娠并发症的风险也不会升高。使用口服避孕药的女性母乳喂养时间不如未使用者长,但在使用口服避孕药的女性和未使用者的子女生长发育方面未发现差异。口服避孕药的使用与垂体腺瘤之间没有关系,与后续闭经之间也没有关系。