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Malignant peripheral nerve cell tumour.恶性周围神经细胞瘤
J Maxillofac Oral Surg. 2010 Mar;9(1):68-71. doi: 10.1007/s12663-010-0019-6. Epub 2010 Jun 4.
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Guidelines for the diagnosis and management of individuals with neurofibromatosis 1.1型神经纤维瘤病患者的诊断和管理指南。
J Med Genet. 2007 Feb;44(2):81-8. doi: 10.1136/jmg.2006.045906. Epub 2006 Nov 14.
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Intraosseous nerve sheath tumors in the jaws.颌骨内神经鞘瘤
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Intraosseous malignant peripheral nerve sheath tumor. Report of a case and review of the literature.骨内恶性外周神经鞘瘤。病例报告及文献复习。
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Solitary neurofibroma of the mandible: case report and review of the literature.下颌骨孤立性神经纤维瘤：病例报告及文献复习
J Oral Maxillofac Surg. 1989 Jan;47(1):65-8. doi: 10.1016/0278-2391(89)90127-4.
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Malignant peripheral nerve sheath tumors: an immunohistochemical study in relation to ultrastructural features.
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Neurilemmoma of the head and neck.
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Intraosseous benign neural sheath neoplasms of the jaws. Report of seven new cases and review of the literature.
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下颌骨恶性外周神经鞘瘤：解决困惑之处

Malignant peripheral nerve sheath tumour (MPNST) of mandible: solving the perplexity.

作者信息

Patel Shilpa, Pathak Jigna, Dekate Kamlesh, Mohanty Neeta

机构信息

Department of Oral Pathology, MGM Dental College & Hospital, Navi Mumbai, Maharashtra, India.

MGM Dental College & Hospital, Navi Mumbai, Maharashtra, India.

出版信息

BMJ Case Rep. 2015 Mar 11;2015:bcr2014207790. doi: 10.1136/bcr-2014-207790.

DOI:10.1136/bcr-2014-207790
PMID:25762575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4693118/
Abstract

We present an extremely rare case of malignant peripheral nerve sheath tumour (MPNST) in a 30-year-old woman without associated neurofibromatosis 1. The patient presented with an 8 cm×4 cm lesion extending from 46 to the retro molar region involving the ramus of the right mandible associated with regional paraesthesia. Incisional biopsy revealed spindle cells with vesicular nuclei arranged in fascicles leading to a diagnosis of spindle cell lesion. Posterior segmental mandibulectomy was performed under general anaesthesia. On excisional biopsy, a definitive diagnosis of low-grade MPNST was established on the basis of immunohistochemistry. The patient was then lost to follow-up.

摘要

我们报告了一例极为罕见的恶性外周神经鞘瘤（MPNST），患者为一名30岁女性，无1型神经纤维瘤病。患者出现一个8厘米×4厘米的病变，从46区延伸至磨牙后区，累及右下颌骨升支，并伴有局部感觉异常。切开活检显示梭形细胞，核呈空泡状，排列成束状，诊断为梭形细胞病变。在全身麻醉下进行了下颌骨后段切除术。切除活检后，根据免疫组织化学结果确诊为低级别MPNST。该患者随后失访。