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The Resistant-Population Cutoff (RCOFF): a New Concept for Improved Characterization of Antimicrobial Susceptibility Patterns of Non-Wild-Type Bacterial Populations.耐药菌群体临界值（RCOFF）：一种用于改进非野生型细菌群体抗菌药敏模式特征描述的新概念。
J Clin Microbiol. 2015 Jun;53(6):1806-11. doi: 10.1128/JCM.03505-14. Epub 2015 Mar 11.
2
Evaluation of carbapenemase screening and confirmation tests with Enterobacteriaceae and development of a practical diagnostic algorithm.肠杆菌科细菌碳青霉烯酶筛查和确认试验的评估及实用诊断算法的开发
J Clin Microbiol. 2015 Jan;53(1):95-104. doi: 10.1128/JCM.01692-14. Epub 2014 Oct 29.
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Integrating forecast probabilities in antibiograms: a way to guide antimicrobial prescriptions more reliably?将预测概率纳入抗菌谱：一种更可靠地指导抗菌药物处方的方法？
J Clin Microbiol. 2014 Oct;52(10):3674-84. doi: 10.1128/JCM.01645-14. Epub 2014 Aug 6.
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A systematic review and meta-analysis of diagnostic accuracy of serum 1,3-β-D-glucan for invasive fungal infection: Focus on cutoff levels.系统评价和荟萃分析血清 1,3-β-D-葡聚糖对侵袭性真菌感染的诊断准确性：重点关注临界值。
J Microbiol Immunol Infect. 2015 Aug;48(4):351-61. doi: 10.1016/j.jmii.2014.06.009. Epub 2014 Jul 28.
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9
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Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).26 家美国医院采集的肠杆菌科菌血症分离株中β-内酰胺酶编码基因的流行率：SENTRY 抗菌药物监测计划（2010 年）的报告。
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一种用于确定基于纸片扩散法的临界值的统计方法，以对抗菌药物敏感性试验中的野生型和非野生型细菌群体进行系统表征。

A statistical approach for determination of disk diffusion-based cutoff values for systematic characterization of wild-type and non-wild-type bacterial populations in antimicrobial susceptibility testing.

作者信息

Valsesia Giorgia, Roos Malgorzata, Böttger Erik C, Hombach Michael

机构信息

Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.

Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.

出版信息

J Clin Microbiol. 2015 Jun;53(6):1812-22. doi: 10.1128/JCM.03506-14. Epub 2015 Mar 11.

DOI:10.1128/JCM.03506-14
PMID:25762772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4432064/
Abstract

In this study, we introduce a new approach for determination of epidemiologic cutoffs (ECOFFs) and resistant-population cutoffs (RCOFFs) based on receiver operating characteristic (ROC) curves. As an example, the method was applied for determination of ECOFFs for seven different beta-lactam antibiotics and wild-type populations of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae. In addition, RCOFFs were determined for bacterial populations with defined resistance mechanisms ("resistotypes"), i.e., extended-spectrum beta-lactamase (ESBL)-positive E. coli, ESBL-positive K. pneumoniae, and ESBL-positive E. cloacae; AmpC cephalosporinase-positive E. coli and AmpC-positive K. pneumoniae; and broad-spectrum beta-lactamase (BSBL)-positive E. coli. RCOFFs and ECOFFs are instrumental for a systematic characterization of associations between resistotypes and wild-type populations.

摘要

在本研究中，我们引入了一种基于受试者工作特征（ROC）曲线来确定流行病学截断值（ECOFFs）和耐药人群截断值（RCOFFs）的新方法。作为示例，该方法被应用于确定七种不同β-内酰胺类抗生素以及大肠杆菌、肺炎克雷伯菌和阴沟肠杆菌野生型群体的ECOFFs。此外，还针对具有明确耐药机制（“耐药型”）的细菌群体确定了RCOFFs，即产超广谱β-内酰胺酶（ESBL）的大肠杆菌、产ESBL的肺炎克雷伯菌和产ESBL的阴沟肠杆菌；产AmpC头孢菌素酶的大肠杆菌和产AmpC的肺炎克雷伯菌；以及产广谱β-内酰胺酶（BSBL）的大肠杆菌。RCOFFs和ECOFFs有助于系统地表征耐药型与野生型群体之间的关联。