Sato M
Department of Psychiatry, Tohoku University Medical School, Sendai, Japan.
Jpn J Psychiatry Neurol. 1989 Sep;43(3):405-10. doi: 10.1111/j.1440-1819.1989.tb02935.x.
Postictal and interictal changes in behavior and the corresponded neurochemical data in the kindling model of epilepsy are reviewed briefly to explore a biological base for epileptic psychosis. Kindling can be a potent animal model to study this problem. A possible participation of both TRH and opioid system in prolonged postictal behavior disorder and of TRH, mesolimbic system and/or PI response to excitatory amino acid in interictal behavior disorder are discussed. A further experimental study is required to disclose the basic mechanism of epileptic psychosis.
