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莲子心提取物对小鼠气道平滑肌的舒张作用。

Relaxant action of plumula nelumbinis extract on mouse airway smooth muscle.

作者信息

Tan Li, Chen Weiwei, Wei Ming-Yu, Shen Jinhua, Yu Meng-Fei, Yang Guangzhong, Guo Donglin, Qin Gangjian, Ji Guangju, Liu Qing-Hua

机构信息

Institute for Medical Biology & Hubei Provincial Key Laboratory for Protection and Application of Special Plant Germplasmin Wuling Area of China, College of Life Sciences, South Central University for Nationalities, Wuhan 430074, China.

College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China.

出版信息

Evid Based Complement Alternat Med. 2015;2015:523640. doi: 10.1155/2015/523640. Epub 2015 Feb 11.

DOI:10.1155/2015/523640
PMID:25763092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4339714/
Abstract

The traditional herb Plumula Nelumbinis is widely used in the world because it has many biological activities, such as anti-inflammation, antioxidant, antihypertension, and butyrylcholinesterase inhibition. However, the action of Plumula Nelumbinis on airway smooth muscle (ASM) relaxation has not been investigated. A chloroform extract of Plumula Nelumbinis (CEPN) was prepared, which completely inhibited precontraction induced by high K(+) in a concentration-dependent manner in mouse tracheal rings, but it had no effect on resting tension. CEPN also blocked voltage-dependent L-type Ca(2+) channel- (VDCC-) mediated currents. In addition, ACh-induced precontraction was also completely blocked by CEPN and partially inhibited by nifedipine or pyrazole 3. Besides, CEPN partially reduced ACh-activated nonselective cation channel (NSCC) currents. Taken together, our data demonstrate that CEPN blocked VDCC and NSCC to inhibit Ca(2+) influx, resulting in relaxation of precontracted ASM. This finding indicates that CEPN would be a candidate of new potent bronchodilators.

摘要

传统草药莲子心在世界范围内被广泛应用，因为它具有多种生物活性，如抗炎、抗氧化、抗高血压以及抑制丁酰胆碱酯酶。然而，莲子心对气道平滑肌（ASM）舒张作用尚未得到研究。制备了莲子心氯仿提取物（CEPN），其在小鼠气管环中以浓度依赖性方式完全抑制高钾（K⁺）诱导的预收缩，但对静息张力无影响。CEPN还阻断电压依赖性L型钙通道（VDCC）介导的电流。此外，CEPN也完全阻断乙酰胆碱（ACh）诱导的预收缩，硝苯地平或吡唑3可部分抑制该作用。此外，CEPN可部分降低ACh激活的非选择性阳离子通道（NSCC）电流。综上所述，我们的数据表明CEPN通过阻断VDCC和NSCC来抑制钙离子内流，从而导致预收缩的ASM舒张。这一发现表明CEPN可能是新型强效支气管扩张剂的候选药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bd/4339714/1556b5a88009/ECAM2015-523640.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bd/4339714/664545f52d53/ECAM2015-523640.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bd/4339714/b12a7e946e77/ECAM2015-523640.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bd/4339714/2431af2b7e50/ECAM2015-523640.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bd/4339714/120cb98ccb9d/ECAM2015-523640.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bd/4339714/26b4d14bbf73/ECAM2015-523640.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bd/4339714/6c837c671fda/ECAM2015-523640.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bd/4339714/1556b5a88009/ECAM2015-523640.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bd/4339714/664545f52d53/ECAM2015-523640.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bd/4339714/b12a7e946e77/ECAM2015-523640.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bd/4339714/2431af2b7e50/ECAM2015-523640.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bd/4339714/120cb98ccb9d/ECAM2015-523640.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bd/4339714/26b4d14bbf73/ECAM2015-523640.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bd/4339714/6c837c671fda/ECAM2015-523640.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bd/4339714/1556b5a88009/ECAM2015-523640.007.jpg

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本文引用的文献

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PLoS One. 2014 Jul 3;9(7):e101578. doi: 10.1371/journal.pone.0101578. eCollection 2014.
2
Total flavonoids from Plumula Nelumbinis suppress angiotensin II-induced fractalkine production by inhibiting the ROS/NF-κB pathway in human umbilical vein endothelial cells.荷叶总黄酮通过抑制人脐静脉内皮细胞中的ROS/NF-κB途径来抑制血管紧张素II诱导的趋化因子生成。
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3
Sci Rep. 2018 Feb 15;8(1):3114. doi: 10.1038/s41598-018-20409-x.
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Nelumbo nucifera leaves extracts inhibit mouse airway smooth muscle contraction.莲（荷叶）提取物抑制小鼠气道平滑肌收缩。
BMC Complement Altern Med. 2017 Mar 20;17(1):159. doi: 10.1186/s12906-017-1674-7.
5
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Evid Based Complement Alternat Med. 2016;2016:8703239. doi: 10.1155/2016/8703239. Epub 2016 Apr 27.
Bitter tastants induce relaxation of rat thoracic aorta precontracted with high K(+).
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