Yen-Koo H C, Balazs T
Toxicology and Pharmacology Branch, Food and Drug Administration, Washington, DC 20204.
Toxicol Ind Health. 1989 Dec;5(6):949-52. doi: 10.1177/074823378900500603.
Cats were trained to obtain food pellets under a cycle reward condition in 4-6 weeks. These conditioned-behavior cats were then used for testing a group of non-psychotropic drugs, and any modification of the feeding cycle (FC) was considered as a side effect of the drug on conditioned behavior. All drugs were given orally. Of the 16 non-psychotropic drugs studied, only indomethacin caused a loss and irregularity in the FC. Antihistamines, acetylsalicylic acid, phenoxybenzamine and amantadine reduced the number of FC by about 50%. Studies of conditioned behavior in the cat appear to be useful for both the investigation of drug interactions and the detection of side effects of drugs not ordinarily considered to have central nervous system effects.
在4至6周内，训练猫在周期性奖励条件下获取食物颗粒。然后，将这些形成条件行为的猫用于测试一组非精神药物，喂食周期（FC）的任何改变都被视为药物对条件行为的副作用。所有药物均口服给药。在所研究的16种非精神药物中，只有吲哚美辛导致喂食周期出现缺失和不规则。抗组胺药、乙酰水杨酸、酚苄明和金刚烷胺使喂食周期的次数减少了约50%。对猫的条件行为研究似乎有助于药物相互作用的研究以及检测通常不被认为具有中枢神经系统作用的药物的副作用。
