Yen-Koo H C, Krop S, Mendez H C
Pharmacology. 1982;25(2):111-5. doi: 10.1159/000137731.
Cats trained in 4-6 weeks to obtain a reward (food pellet) were made 'neurotic' by a randomly occurring air blast at the reward box. Previous studies have shown that d-amphetamine facilitates development of 'neurotic' (conflict-induced) behavior. Caffeine, another stimulant, was examined to determine how it affects positive reinforcement behavior, induction of 'neurosis' and its interaction with depressants. Caffeine, given orally, induced stereotyped behavior, facilitated development of the 'neurotic' behavior and disrupted the feeding cycle. Chlorpromazine, pentobarbital, diazepam, prazepam and fluazepam delayed the onset of the caffeine-facilitated conflict behavior. Phenobarbital antagonized the caffeine effect. Studies of conflict-induced behavior in the cat appear to be useful for the investigation of drug interactions and for the detection of side effects of drugs that are not ordinarily considered to have effects on the central nervous system.
在4至6周内接受训练以获取奖励（食物颗粒）的猫，在奖励箱处会受到随机出现的气浪冲击，从而变得“神经质”。先前的研究表明，右旋苯丙胺会促进“神经质”（冲突诱发）行为的发展。另一种兴奋剂咖啡因也接受了检测，以确定它如何影响正强化行为、“神经症”的诱发以及它与抑制剂的相互作用。口服咖啡因会诱发刻板行为，促进“神经质”行为的发展并扰乱进食周期。氯丙嗪、戊巴比妥、地西泮、普拉西泮和氟西泮会延迟咖啡因促进的冲突行为的发作。苯巴比妥会拮抗咖啡因的作用。对猫的冲突诱发行为的研究似乎有助于药物相互作用的研究以及检测通常被认为对中枢神经系统没有影响的药物的副作用。
