Kasim Khaled, Roshdy Ahmed
Department of Public Health and Community Medicine, Faculty of Medicine, Al-Azhar University, Nasr City, Cairo, Egypt.
Assisted Reproductive Technology (ART) Unit, International Islamic Centre for Population Studies and Research (IICPSR), Al-Azhar University, Cairo, Egypt.
Int J Reprod Med. 2014;2014:257974. doi: 10.1155/2014/257974. Epub 2014 Mar 5.
The present study aimed to evaluate the impact of body mass index (BMI) on pregnancy outcome after intracytoplasmic sperm injection (ICSI). The study analyzed pregnancy outcome of 349 women who underwent ICSI by their BMI: <25, 25-<30, and ≥30 kg/m(2). The associations were generated by applying logistic regression models. A significant reduction in positive pregnancy outcome was observed among overweight and obese women (odds ratio (OR) = 0.50; 95% confidence interval (CI) = 0.25-0.99 for overweight women and OR = 0.45; 95% CI = 0.20-0.89 for obese women). These estimates show that the pregnancy rates are reduced with increasing BMI. The effect of obesity on pregnancy outcome was absent when three and more embryos were transferred. Our study contributes to the reports linking overweight and obesity with decreased positive pregnancy outcome after ICSI and suggests women's age, infertility type, and number of embryos transferred to modify this reducing effect.
本研究旨在评估体重指数（BMI）对卵胞浆内单精子注射（ICSI）后妊娠结局的影响。该研究根据BMI将349例行ICSI的女性分为：<25、25至<30以及≥30kg/m²三组，并分析了她们的妊娠结局。通过应用逻辑回归模型得出相关关联。超重和肥胖女性的妊娠阳性结局显著降低（超重女性的比值比（OR）=0.50；95%置信区间（CI）=0.25 - 0.99，肥胖女性的OR = 0.45；95%CI = 0.20 - 0.89）。这些估计表明，随着BMI的增加，妊娠率降低。当移植三个及以上胚胎时，肥胖对妊娠结局的影响消失。我们的研究为超重和肥胖与ICSI后妊娠阳性结局降低之间的关联报告做出了贡献，并表明女性年龄、不孕类型以及移植胚胎数量可改变这种降低效应。
